HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Althaus, C. L. Articles by De Boer, R. J. Search for Related Content PubMed PubMed Citation Articles by Althaus, C. L. Articles by De Boer, R. J.

Dynamics of CD8⁺ T Cell Responses during Acute and Chronic Lymphocytic Choriomeningitis Virus Infection¹

Theoretical Biology, Utrecht University, Utrecht, The Netherlands

Infection of mice with lymphocytic choriomeningitis virus (LCMV) is frequently used to study the underlying principles of viral infections and immune responses. We fit a mathematical model to recently published data characterizing Ag-specific CD8⁺ T cell responses during acute (Armstrong) and chronic (clone 13) LCMV infection. This allows us to analyze the differences in the dynamics of CD8⁺ T cell responses against different types of LCMV infections. For the four CD8⁺ T cell responses studied, we find that, compared with the responses against acute infection, responses against chronic infection are generally characterized by an earlier peak and a faster contraction phase thereafter. Furthermore, the model allows us to give a new interpretation of the effect of thymectomy on the dynamics of CD8⁺ T cell responses during chronic LCMV infection: a smaller number of naive precursor cells is sufficient to account for the observed differences in the responses in thymectomized mice. Finally, we compare data characterizing LCMV-specific CD8⁺ T cell responses from different laboratories. Although the data were derived from the same experimental model, we find quantitative differences that can be solved by introducing a scaling factor. Also, we find kinetic differences that are at least partly due to the infrequent measurements of CD8⁺ T cells in the different laboratories.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ C.L.A. and R.J.D.B. received financial support from Netherlands Organization for Scientific Research Grant 016.048.603. V.V.G. is supported by a Marie Curie Incoming International Fellowship (FP6).

² Address correspondence and reprint requests to Christian L. Althaus, Theoretical Biology, Utrecht University, 3584 CH Utrecht, The Netherlands. E-mail address: c.l.althaus{at}uu.nl

³ Abbreviations used in this paper: LCMV, lymphocytic choriomeningitis virus; p.i., postinfection; SThx, sham-thymectomized; Thx, thymectomized; CI, confidence interval.

This article has been cited by other articles:

				M. F. Kotturi, I. Scott, T. Wolfe, B. Peters, J. Sidney, H. Cheroutre, M. G. von Herrath, M. J. Buchmeier, H. Grey, and A. Sette Naive Precursor Frequencies and MHC Binding Rather Than the Degree of Epitope Diversity Shape CD8+ T Cell Immunodominance J. Immunol., August 1, 2008; 181(3): 2124 - 2133. [Abstract] [Full Text] [PDF]