The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


The Journal of Immunology, 2007, 179, 1423 -1426
Copyright © 2007 by The American Association of Immunologists, Inc.

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Kryczek, I.
Right arrow Articles by Zou, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kryczek, I.
Right arrow Articles by Zou, W.

Cutting Edge: Opposite Effects of IL-1 and IL-2 on the Regulation of IL-17+ T Cell Pool IL-1 Subverts IL-2-Mediated Suppression1

Ilona Kryczek*, Shuang Wei*, Linhua Vatan*, June Escara-Wilke{dagger}, Wojciech Szeliga*, Evan T. Keller{dagger} and Weiping Zou2,*

* Department of Surgery and {dagger} Department of Urology, University of Michigan, Ann Arbor, MI 48109

In this report, we show that IL-17+CD4+ and IL-17+CD8+ T cells are largely found in lung and digestive mucosa compartments in normal mice. Endogenous and exogenous IL-1 dramatically contribute to IL-17+ T cell differentiation mediated by TGFbeta and IL-6. IL-1 is capable of stimulating IL-17+ T cell differentiation in the absence of IL-6. Furthermore, although IL-2 reduces IL-17+ T cell differentiation, IL-1 completely disables this effect. Mechanistically, IL-1 and IL-2 play opposite roles in regulating the expression of several molecules regulating Th17 cell differentiation, including the orphan nuclear receptor ROR{gamma}t, the IL-1 receptor, and the IL-23 receptor. IL-1 subverts the effects of IL-2 on the expression of these gene transcripts. Altogether, our work demonstrates that IL-6 is important but not indispensable for IL-17+ T cell differentiation and that IL-1plays a predominant role in promoting IL-17+ T cell induction. Thus, the IL-17+ T cell pool may be controlled by the local cytokine profile in the microenvironment.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

1 This work was supported by the National Cancer Institute (to W.Z.).

2 Address correspondence and reprint requests to Dr. Weiping Zou, C560B Medical Science Research Building II, Ann Arbor, MI 48109. E-mail address: wzou{at}umich.edu




This article has been cited by other articles:


Home page
Int ImmunolHome page
J. Hong, H. Li, M. Chen, Y. C. Q. Zang, S. M. Skinner, J. M. Killian, and J. Z. Zhang
Regulatory and pro-inflammatory phenotypes of myelin basic protein-autoreactive T cells in multiple sclerosis
Int. Immunol., December 1, 2009; 21(12): 1329 - 1340.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
G. Murugaiyan, A. Mittal, R. Lopez-Diego, L. M. Maier, D. E. Anderson, and H. L. Weiner
IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells
J. Immunol., August 15, 2009; 183(4): 2435 - 2443.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
I. Kryczek, M. Banerjee, P. Cheng, L. Vatan, W. Szeliga, S. Wei, E. Huang, E. Finlayson, D. Simeone, T. H. Welling, et al.
Phenotype, distribution, generation, and functional and clinical relevance of Th17 cells in the human tumor environments
Blood, August 6, 2009; 114(6): 1141 - 1149.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
I. Kryczek, S. Wei, W. Szeliga, L. Vatan, and W. Zou
Endogenous IL-17 contributes to reduced tumor growth and metastasis
Blood, July 9, 2009; 114(2): 357 - 359.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
K. Ichiyama, M. Hashimoto, T. Sekiya, R. Nakagawa, Y. Wakabayashi, Y. Sugiyama, K. Komai, I. Saba, T. Moroy, and A. Yoshimura
Gfi1 negatively regulates Th17 differentiation by inhibiting ROR{gamma}t activity
Int. Immunol., July 1, 2009; 21(7): 881 - 889.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
B. Ciric, M. El-behi, R. Cabrera, G.-X. Zhang, and A. Rostami
IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells
J. Immunol., May 1, 2009; 182(9): 5296 - 5305.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
M. J. Carlson, M. L. West, J. M. Coghill, A. Panoskaltsis-Mortari, B. R. Blazar, and J. S. Serody
In vitro-differentiated TH17 cells mediate lethal acute graft-versus-host disease with severe cutaneous and pulmonary pathologic manifestations
Blood, February 5, 2009; 113(6): 1365 - 1374.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
I. Kryczek, S. Wei, W. Gong, X. Shu, W. Szeliga, L. Vatan, L. Chen, G. Wang, and W. Zou
Cutting Edge: IFN-{gamma} Enables APC to Promote Memory Th17 and Abate Th1 Cell Development
J. Immunol., November 1, 2008; 181(9): 5842 - 5846.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
G. L. Stritesky, N. Yeh, and M. H. Kaplan
IL-23 Promotes Maintenance but Not Commitment to the Th17 Lineage
J. Immunol., November 1, 2008; 181(9): 5948 - 5955.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
E. C. Lewis, M. Mizrahi, M. Toledano, N. DeFelice, J. L. Wright, A. Churg, L. Shapiro, and C. A. Dinarello
{alpha}1-Antitrypsin monotherapy induces immune tolerance during islet allograft transplantation in mice
PNAS, October 21, 2008; 105(42): 16236 - 16241.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
I. Kryczek, A. T. Bruce, J. E. Gudjonsson, A. Johnston, A. Aphale, L. Vatan, W. Szeliga, Y. Wang, Y. Liu, T. H. Welling, et al.
Induction of IL-17+ T Cell Trafficking and Development by IFN-{gamma}: Mechanism and Pathological Relevance in Psoriasis
J. Immunol., October 1, 2008; 181(7): 4733 - 4741.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
K. M. Dhodapkar, S. Barbuto, P. Matthews, A. Kukreja, A. Mazumder, D. Vesole, S. Jagannath, and M. V. Dhodapkar
Dendritic cells mediate the induction of polyfunctional human IL17-producing cells (Th17-1 cells) enriched in the bone marrow of patients with myeloma
Blood, October 1, 2008; 112(7): 2878 - 2885.
[Abstract] [Full Text] [PDF]


Home page
BloodHome page
H. J. P. M. Koenen, R. L. Smeets, P. M. Vink, E. van Rijssen, A. M. H. Boots, and I. Joosten
Human CD25highFoxp3pos regulatory T cells differentiate into IL-17-producing cells
Blood, September 15, 2008; 112(6): 2340 - 2352.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2007 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2007 by The American Association of Immunologists, Inc. All rights reserved.