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* Department of Immunology, University of Connecticut Health Center, Farmington, CT 06030; and
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan
Memory CD8 T cells, essential for defense against intracellular pathogens, are heterogeneous with respect to phenotype and function. Constitutively lytic effector memory cells primarily reside in nonlymphoid tissues, whereas secondary lymphoid tissues contain functionally quiescent central memory cells. However, the mechanism by which functionally distinct memory populations are maintained is unknown. In this study, we show that resting CD8 memory cells modified their functional abilities upon entry into nonlymphoid tissues, as exemplified by the induction of granzyme B and lytic activity. Contemporaneously, the costimulator CD27 was down-regulated. These findings hold important implications for memory cell lineage development and tissue-specific immunity.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by National Institutes of Health Grant DK45260.
2 Address correspondence and reprint requests to: Dr. Leo Lefrançois, Department of Immunology, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT 06030-1319. E-mail address: llefranc{at}neuron.uchc.edu
3 Abbreviations used in this paper: TCM, central memory T cells; B6, C57BL/6; LM-ova, Listeria monocytogenes expressing ova; VSV-ova, vesicular stomatitis virus encoding ovalbumin; TEM, effector memory T cells; MFI, mean fluorescence intensity.
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