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-Catenin Expression Enhances IL-7 Receptor Signaling in Thymocytes during Positive Selection¹

Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, National Institutes of Health, Baltimore, MD 21224

Differentiation of CD4⁺CD8⁺ double-positive thymocytes into CD8⁺ single-positive (SP) thymocytes is regulated by TCR and cytokine receptor signals. Previously, we have shown that expression of stabilized -catenin, the major transcriptional cofactor of T cell factor, results in increase in both CD4SP and CD8SP thymocytes with a preferential effect on CD8SP thymocytes. In this report, using mice expressing stabilized -catenin and mice with T cell specific deletion of -catenin, we show that -catenin expression augments IL-7R-chain expression and down-regulates suppressor of cytokine signaling-1 expression in thymocytes undergoing positive selection. Consequently, -catenin expression augments IL-7R signaling in thymocytes during positive selection and promotes the development of CD8SP thymocytes.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by the Intramural Research Program of the National Institute on Aging at the National Institutes of Health.

² Address correspondence and reprint requests to Dr. Jyoti Misra Sen, Lymphocyte Development Unit, Laboratory of Immunology, National Institute on Aging, Gerontology Research Center, Room 4-B-08, 5600 Nathan Shock Drive, Baltimore, MD 21224. E-mail address: Jyoti-Sen{at}NIH.gov

³ Abbreviations used in this paper: DP, double positive; SP, single positive; _c, common cytokine receptor chain; FTOC, fetal thymic organ culture; SOCS, suppressor of cytokine signaling; CAT-KO, deficiency of -catenin; MFI, mean fluorescence intensity.

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