| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Immunology, Baylor College of Medicine, Houston, TX 77030
Germinal center (GC) reaction is a T cell-dependent process in which activated B cells mature to produce high-affinity Abs and differentiate into memory B cells. The GC microenvironment is almost exclusively reserved for the optimal Ag-specific B cell clonal expansion, selection, and maturation, but lack significant conventional CD4+ T cell responses. The mechanisms that ensure such a focused B cell response in the GC are not known. In this study, we report that human CD4+CD57+ T cells, which are the major helper T cells in GCs, actively suppress the activation of conventional CD4+ T cells, particularly Th1 cells, via a direct contact-dependent mechanism and soluble mediators. Our findings demonstrate that GC T cells are unique regulatory cells that provide critical help signals for B cell response but suppress conventional effector T cells in the same local environment.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 Address correspondence and reprint requests to Dr. Biao Zheng, Department of Immunology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030. E-mail address: bzheng{at}bcm.edu
2 Abbreviations used in this paper: GC, germinal center; FDC, follicular dendritic cell; L, ligand; SA, streptavidin; mIgG1, mouse IgG1; Treg, regulatory T cell; FoxP3, forkhead box P3; GITR, glucocorticoid-induced TNF-like receptor; Tr1, type 1 T regulatory; Th3, type 3 Th.
This article has been cited by other articles:
|
|
 |
|
  J. Carreras, A. Lopez-Guillermo, G. Roncador, N. Villamor, L. Colomo, A. Martinez, R. Hamoudi, W. J. Howat, E. Montserrat, and E. Campo High Numbers of Tumor-Infiltrating Programmed Cell Death 1-Positive Regulatory Lymphocytes Are Associated With Improved Overall Survival in Follicular Lymphoma J. Clin. Oncol., March 20, 2009; 27(9): 1470 - 1476. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Rojo, E. Pini, G. Ojeda, R. Bello, C. Dong, R. A. Flavell, U. Dianzani, and P. Portoles CD4+ICOS+ T lymphocytes inhibit T cell activation 'in vitro' and attenuate autoimmune encephalitis 'in vivo' Int. Immunol., April 1, 2008; 20(4): 577 - 589. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Y. Lee, W. Cho, J. Kim, C.-S. Park, and J. Choe Human Follicular Dendritic Cells Interact with T Cells via Expression and Regulation of Cyclooxygenases and Prostaglandin E and I Synthases J. Immunol., February 1, 2008; 180(3): 1390 - 1397. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Tzankov, C. Meier, P. Hirschmann, P. Went, S. A. Pileri, and S. Dirnhofer Correlation of high numbers of intratumoral FOXP3+ regulatory T cells with improved survival in germinal center-like diffuse large B-cell lymphoma, follicular lymphoma and classical Hodgkin's lymphoma Haematologica, February 1, 2008; 93(2): 193 - 200. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Focosi and M. Petrini Comment on "Germinal Center Helper T Cells Are Dual Functional Regulatory Cells with Suppressive Activity to Conventional CD4+ T Cells" J. Immunol., July 15, 2007; 179(2): 731 - 731. [Full Text] [PDF]
|
|
|
|
|
|
E. Marinova, S. Han, and B. Zheng Response to Comment on "Germinal Center Helper T Cells Are Dual Functional Regulatory Cells with Suppressive Activity to Conventional CD4+ T Cells" J. Immunol., July 15, 2007; 179(2): 731 - 732. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
