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The Bxs6 Locus of BXSB Mice Is Sufficient for High-Level Expression of gp70 and the Production of gp70 Immune Complexes¹

Joanna Rankin^*, Joseph J. Boyle, S. Jane Rose^*, Luisa Gabriel^*, Margarita Lewis^*, Vasuky Thiruudaian^*, Nicola J. Rogers, Shozo Izui and Bernard J. Morley^2,*

^* Rheumatology Section, Immunology Department, and Histopathology Department, Imperial College, London, United Kingdom; and Department of Pathology and Immunology, Centre Médical Universitaire, Geneva, Switzerland

High levels of the retroviral envelope protein gp70 and gp70 immune complexes have been linked to a single locus on chromosome 13 (Bxs6) in the BXSB model, to which linkage of nephritis was also seen. Congenic lines containing the BXSB Bxs6 interval on a non-autoimmune C57BL/10 background were bred in the presence or absence of the BXSB Y chromosome autoimmune accelerator gene (Yaa), which accelerates disease in male mice. In these mice, we have shown that Bxs6 is sufficient to cause high-level expression of gp70 and the production of gp70 autoantibodies, independently of Yaa, with gp70 immune complex levels enhanced by Yaa. In the presence of Yaa, Bxs6 also causes mild nephritis, and interestingly the sporadic production of high levels of anti-DNA Abs in some mice. Fine mapping using rare recombinant mice suggested that Bxs6 lies between 59.7 and 74.8 megabases (Mb), although the interval of 0.6 Mb between 73.6 and 78.6 Mb on chromosome 13 cannot be excluded in this study.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by grants from the Arthritis Research Campaign (U.K.; to B.J.M.) and the Swiss National Foundation for Scientific Research (to S.I.).

² Address correspondence and reprint requests to Dr. Bernard J. Morley, Rheumatology Section, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12 0NN, U.K. E-mail address: b.morley{at}imperial.ac.uk

³ Abbreviations used in this paper: SLE, systemic lupus erythematosus; ANA, anti-nuclear Ab; gp70IC, gp 70 immune complex; SNP, single nucleotide polymorphism; Mb, megabase; Yaa, Y chromosome autoimmune accelerator gene.