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CUTTING EDGE |
* Division of Immunobiology Cincinnati Children’s Hospital, Department of Pediatrics at the University of Cincinnati College of Medicine, Cincinnati, Ohio 45229; and
Institute for Cellular Therapeutics and the University of Louisville Department of Microbiology and Immunology, Louisville, KY 40202
During the acute T cell response most effector T cells die while some survive and become memory T cells. Selective expression of CD127 (IL-7R
) on effector T cells has been proposed to engender their survival into the memory pool. We assessed the role of IL-7 in effector T cell survival using MHC class II tetramers to track a CD4+ T cell response following infection with a recombinant vaccinia virus (rVV-2W1S). Exogenous IL-7 prevented the contraction of the 2W1S-specific CD4+ T cell response after rVV-2W1S infection. IL-7 increased proliferation of, and Bcl-2 expression within, 2W1S-specific T cells; the latter was required for IL-7-driven prevention of contraction. Conversely, in vivo neutralization of IL-7 or Bcl-2 did not exacerbate the contraction of 2W1S-specific CD4+ T cells. These data suggest that IL-7 administration may enhance the survival of effector T cells but that IL-7 is not the limiting factor during normal contraction of the response.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by start-up funds from the Division of Immunobiology, a Trustee Grant from Cincinnati Children’s Hospital Research Foundation, and Public Health Service Grant AI057753 (to D.A.H.).
2 Address correspondence and reprint requests to Dr. David A. Hildeman, Department of Pediatrics, Division of Immunobiology, Mail Location Code 7038, Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, OH 45229. E-mail address: David.Hildeman{at}cchmc.org
3 Abbreviations used in this paper: LCMV, lymphocytic choriomeningitis virus; BM, bone marrow; BSS, balanced salt solution; IC, immune complex; int, intermediate; rVV, recombinant vaccinia virus.
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