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HIV-Specific IL-10-Positive CD8⁺ T Cells Suppress Cytolysis and IL-2 Production by CD8⁺ T Cells¹

Mohamed Elrefaei^2,*, Florence L. Ventura^*, Chris A. R. Baker^*, Richard Clark, David R. Bangsberg and Huyen Cao^*

^* California Department of Health Services, Richmond, CA 94804; and Department of Medicine, University of California, San Francisco, CA 94143

IL-10 producing T cells inhibit Ag-specific CD8⁺ T cell responses and may play a role in the immune dysregulation observed in HIV infection. We have previously observed the presence of HIV-specific IL-10-positive CD8⁺ T cells in advanced HIV disease. In this study, we examined the suppressive function of the Gag-specific IL-10-positive CD8⁺ T cells. Removal of these IL-10-positive CD8⁺ T cells resulted in increased cytolysis and IL-2, but not IFN-, production by both HIV- and human CMV-specific CD8⁺ T cells. In addition, these IL-10-positive CD8⁺ T cells mediated suppression through direct cell-cell contact, and had a distinct immunophenotypic profile compared with other regulatory T cells. We describe a new suppressor CD8⁺ T cell population in advanced HIV infection that may contribute to the immune dysfunction observed in HIV infection.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants AI43885 and MH54907.

² Address correspondence and reprint requests to Dr. Mohamed Elrefaei, California Department of Health Services, 850 Marina Bay Parkway, Viral and Rickettsial Disease Laboratory, Richmond, CA, 94804. E-mail address: melrefae{at}dhs.ca.gov

³ Abbreviations used in this paper: HCMV, human CMV; ILT, Ig-like transcript.

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