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Cutting Edge: Transitional T3 B Cells Do Not Give Rise to Mature B Cells, Have Undergone Selection, and Are Reduced in Murine Lupus¹

Brittany N. Teague^*, Yujun Pan^*, Philip A. Mudd^*, Britt Nakken^*, Qingzhao Zhang, Peter Szodoray, Xana Kim-Howard^*, Patrick C. Wilson and A. Darise Farris^2,*

^* Arthritis and Immunology Research Program and Molecular Immunogenetics Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104

As the immediate precursors to mature follicular B cells in splenic development, immature transitional cells are an essential component for understanding late B cell differentiation. It has been shown that T2 cells can give rise to mature B cells; however, whether T3 B cells represent a normal stage of B cell development, which has been widely assumed, has not been fully resolved. In this study, we demonstrate both in vitro and in vivo that T3 B cells do not give rise to mature B cells and are instead selected away from the T1T2mature B cell developmental pathway and are hyporesponsive to stimulation through the BCR. Significantly reduced numbers of T3 B cells in young lupus-prone mice further suggest that the specificity of this subset holds clues to understanding autoimmunity.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by National Institutes of Health Grants P50 AR 48940, KO2 AI51647, and R01 AI48097.

² Address correspondence and reprint requests to Dr. A. Darise Farris, Oklahoma Medical Research Foundation, 825 North East 13th Street, Oklahoma City, OK 73104. E-mail address: farrisd{at}omrf.ouhsc.edu

³ Abbreviations used in this paper: BM, bone marrow; MB, mature follicular B cell; MZ, marginal zone; BAFF, B cell-activating factor; SLE, systemic lupus erythematosus; s, soluble; SA, streptavidin; int, intermediate; HEL, hen egg lysozyme.

⁴ The online version of this article contains supplemental material.

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