HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Schori, H. Articles by Schwartz, M. Search for Related Content PubMed PubMed Citation Articles by Schori, H. Articles by Schwartz, M. Pubmed/NCBI databases Gene GEO Profiles HomoloGene UniGene

Genetic Manipulation of CD74 in Mouse Strains of Different Backgrounds Can Result in Opposite Responses to Central Nervous System Injury

Hadas Schori^*, Ravid Shechter^*, Idit Shachar and Michal Schwartz^1,*

^* Departments of Neurobiology and Immunology, The Weizmann Institute of Science, 76100 Rehovot, Israel

The ability to recover from CNS injuries is strain dependent. Transgenic mice that weakly express the p41 CD74 isoform (an integral membrane protein functioning as a MHC class II chaperone) on an I-A^b genetic background have normal CD4⁺ T cell populations and normal surface expression of MHC class II, but their B cell development is arrested while the cells are still immature. After a CNS injury, these mice recover better than their matched wild-type controls. We generated p41-transgenic mice on an I-A^d background (p41-I-A^d mice), and found that their recovery from CNS injuries was worse than that of controls. A correlative inverse effect was seen with respect to the kinetics of T cell and B cell recruitment to the injured CNS and the expression of insulin-like growth factor at the lesion site. These results, besides verifying previous findings that B cells function in the damaged CNS, demonstrate that the outcome of a particular genetic manipulation may be strain dependent.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ Address correspondence and reprint requests to Dr. Michal Schwartz, Department of Neurobiology, The Weizmann Institute of Science, 76100 Rehovot, Israel. E-mail address: Michal.Schwartz{at}weizmann.ac.il

² Abbreviations used in this paper: Ii, invariant chain; MHC-II, MHC class II; KO, knockout; WT, wild type; IGF, insulin-like growth factor; RGC, retinal ganglion cell; I-B4, isolectin B4; BDNF, brain-derived neurotrophic factor.

This article has been cited by other articles:

				S. Rossignol, M. Schwab, M. Schwartz, and M. G. Fehlings Spinal Cord Injury: Time to Move? J. Neurosci., October 31, 2007; 27(44): 11782 - 11792. [Abstract] [Full Text] [PDF]