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CXCR5 Identifies a Subset of V9V2 T Cells which Secrete IL-4 and IL-10 and Help B Cells for Antibody Production¹

Nadia Caccamo^*, Luca Battistini, Marc Bonneville, Fabrizio Poccia, Jean Jacques Fournié^¶, Serena Meraviglia^*, Giovanna Borsellino, Richard A. Kroczek^||, Carmela La Mendola^*, Emmanuel Scotet, Francesco Dieli^2,* and Alfredo Salerno^*

^* Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Palermo, Italy; Neuroimmunology Unit, Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy; Institut National de la Santé et de la Recherche Médicale (Inserm) Unité 601, Institut de Biologie, Nantes, France; Laboratory of Immunology, National Institute for Infectious Diseases "L. Spallanzani," Rome, Italy; ^¶ Inserm, Unité 563, Centre de Physiopathologie de Toulouse Purpan, Toulouse, France; and ^|| Molecular Immunology, Robert Koch Institute, Berlin, Germany

V9V2 T lymphocytes recognize nonpeptidic Ags and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in Ab-mediated immune responses. We show here that expression of CXCR5 identifies a unique subset of V9V2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4, and IL-10 and help B cells for Ab production. These properties portray CXCR5⁺V9V2 T cells as a distinct memory T cell subset with B cell helper function.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

¹ This work was supported by grants from the Commission of the European Union, 6FP, contract LSHP-CT-2003-503367, TB-VAC. F.D. was supported by grants from the University of Palermo.

² Address correspondence and reprint requests to Dr. Francesco Dieli, Dipartimento di Biopatologia e Metodologie Biomediche, Università di Palermo, Corso Tukory 211, Palermo 90134 Italy. E-mail address: dieli{at}unipa.it

³ Abbreviations used in this paper: T_CM, central memory T; T_EM, effector memory T; BrHPP, bromohydrinpyrophosphate; Th_F, follicular B Th cell.

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