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* Division of Pediatric Rheumatology, Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110;
Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden;
University of California, San Francisco, CA 94143;
Genetics Institute, Wyeth Research, Cambridge, MA 02140;
¶ Department of Experimental Medicine and Pathology, University La Sapienza, Rome, Italy;
|| Centre d’Immunologie de Marseille-Luminy, Centre National de la Recherche Scientifique-Institut National de la Sante et de la Recherche Medicale-Universite de la Mediterranee, Marseille, France; and
# Howard Hughes Medical Institute and Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110
NK cells vigorously proliferate during viral infections. During the course of murine CMV infection, this response becomes dominated by the preferential proliferation of NK cells that express the activation receptor Ly49H. The factors driving such selective NK cell proliferation have not been characterized. In this study, we demonstrate that preferential NK cell proliferation is dependent on DAP12-mediated signaling following the binding of Ly49H to its virally encoded ligand, m157. Ly49H signaling through DAP12 appears to directly augment NK cell sensitivity to low concentrations of proproliferative cytokines such as IL-15. The impact of Ly49H-mediated signaling on NK cell proliferation is masked in the presence of high concentrations of proproliferative cytokines that nonselectively drive all NK cells to proliferate.
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1 This research was supported by a National Institute of Allergy and Infectious Diseases K08 Grant and a Howard Hughes Medical Institute Faculty Development Award (to A.R.F.); Barnes-Jewish Hospital Research Foundation and National Institutes of Health grants to W.M.Y., who is a Howard Hughes Medical Institute investigator; and grants from the Erik and Edith Fernströms Stiftelse för Medicinsk Forskning and the Swedish Research Council (to K.K. and H.S.).
2 Address correspondence and reprint requests to Dr. Anthony R. French, Washington University, Box 8208, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail address: french_a{at}kids.wustl.edu
3 Abbreviations used in this paper: MCMV, murine CMV; DAP12, DNAX-activation protein 12; p.i., postinfection; SI, selectivity index; wt, wild type.
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