| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
T Cells rather than CD4 T Cells during Mycobacterium tuberculosis Infection1
Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261
IL-17 is a cytokine produced by T cells in response to IL-23. Recent data support a new subset of CD4 Th cells distinct from Th1 or Th2 cells that produce IL-17 and may contribute to inflammation. In this study, we demonstrate that, in naive mice, as well as during Mycobacterium tuberculosis infection, IL-17 production is primarily from 
T cells and other non-CD4+CD8+ cells, rather than CD4 T cells. The production of IL-17 by these cells is stimulated by IL-23 alone, and strongly induced by the cytokines, including IL-23, produced by M. tuberculosis-infected dendritic cells. IL-23 is present in the lungs early in infection and the IL-17-producing cells, such as T cells, may represent a central innate protective response to pulmonary infection.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by National Institutes of Health Grants RO1 AI50732 and AI37859 (to J.L.F.), T32 CA82084-07 (to E.L.), and AI060525 (to A.M.G.) and C Advisors Grant.
2 Address correspondence and reprint requests to Dr. JoAnne L. Flynn, W1157 Biomedical Science Tower, Pittsburgh, PA 15261. E-mail address: joanne{at}pitt.edu
3 Abbreviations used in this paper: BCG, bacillus Calmette-Guérin; KO, knockout; DC, dendritic cell.
This article has been cited by other articles:
|
|
 |
|
  X. Zhou, Q. Chen, J. Moore, J. K. Kolls, S. Halperin, and J. Wang Critical Role of the Interleukin-17/Interleukin-17 Receptor Axis in Regulating Host Susceptibility to Respiratory Infection with Chlamydia Species Infect. Immun., November 1, 2009; 77(11): 5059 - 5070. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Brucklacher-Waldert, K. Steinbach, M. Lioznov, M. Kolster, C. Holscher, and E. Tolosa Phenotypical Characterization of Human Th17 Cells Unambiguously Identified by Surface IL-17A Expression J. Immunol., November 1, 2009; 183(9): 5494 - 5501. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Smith, S. von Vietinghoff, M. A. Stark, A. Zarbock, J. M. Sanders, A. Duley, J. Rivera-Nieves, T. P. Bender, and K. Ley T-Lineage Cells Require the Thymus but Not V(D)J Recombination to Produce IL-17A and Regulate Granulopoiesis In Vivo J. Immunol., November 1, 2009; 183(9): 5685 - 5693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Paidipally, S. Periasamy, P. F. Barnes, R. Dhiman, M. Indramohan, D. E. Griffith, D. Cosman, and R. Vankayalapati NKG2D-Dependent IL-17 Production by Human T Cells in Response to an Intracellular Pathogen J. Immunol., August 1, 2009; 183(3): 1940 - 1945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. von Vietinghoff and K. Ley IL-17A Controls IL-17F Production and Maintains Blood Neutrophil Counts in Mice J. Immunol., July 15, 2009; 183(2): 865 - 873. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Zhang, L. Gao, L. Lei, Y. Zhong, P. Dube, M. T. Berton, B. Arulanandam, J. Zhang, and G. Zhong A MyD88-Dependent Early IL-17 Production Protects Mice against Airway Infection with the Obligate Intracellular Pathogen Chlamydia muridarum J. Immunol., July 15, 2009; 183(2): 1291 - 1300. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Fenoglio, A. Poggi, S. Catellani, F. Battaglia, A. Ferrera, M. Setti, G. Murdaca, and M. R. Zocchi V{delta}1 T lymphocytes producing IFN-{gamma} and IL-17 are expanded in HIV-1-infected patients and respond to Candida albicans Blood, June 25, 2009; 113(26): 6611 - 6618. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Nichols, A. L. Aldrich, M. M. Mariani, D. Vidlak, N. Esen, and T. Kielian TLR2 Deficiency Leads to Increased Th17 Infiltrates in Experimental Brain Abscesses J. Immunol., June 1, 2009; 182(11): 7119 - 7130. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rahman, B. Gudetta, J. Fink, A. Granath, S. Ashenafi, A. Aseffa, M. Derbew, M. Svensson, J. Andersson, and S. G. Brighenti Compartmentalization of Immune Responses in Human Tuberculosis: Few CD8+ Effector T Cells but Elevated Levels of FoxP3+ Regulatory T Cells in the Granulomatous Lesions Am. J. Pathol., June 1, 2009; 174(6): 2211 - 2224. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Ayyoub, F. Deknuydt, I. Raimbaud, C. Dousset, L. Leveque, G. Bioley, and D. Valmori Human memory FOXP3+ Tregs secrete IL-17 ex vivo and constitutively express the TH17 lineage-specific transcription factor ROR{gamma}t PNAS, May 26, 2009; 106(21): 8635 - 8640. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Chen, E. Ahmed, T. Wang, Y. Wang, J. Ochando, A. S. Chong, and M.-L. Alegre TLR Signals Promote IL-6/IL-17-Dependent Transplant Rejection J. Immunol., May 15, 2009; 182(10): 6217 - 6225. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. L. Simonian, C. L. Roark, F. Wehrmann, A. M. Lanham, W. K. Born, R. L. O'Brien, and A. P. Fontenot IL-17A-Expressing T Cells Are Essential for Bacterial Clearance in a Murine Model of Hypersensitivity Pneumonitis J. Immunol., May 15, 2009; 182(10): 6540 - 6549. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Awasthi and V. K. Kuchroo Th17 cells: from precursors to players in inflammation and infection Int. Immunol., May 1, 2009; 21(5): 489 - 498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Siegemund, N. Schutze, S. Schulz, K. Wolk, K. Nasilowska, R. K. Straubinger, R. Sabat, and G. Alber Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis Int. Immunol., May 1, 2009; 21(5): 555 - 565. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Bordon, C. A. H. Hansell, D. P. Sester, M. Clarke, A. McI. Mowat, and R. J. B. Nibbs The Atypical Chemokine Receptor D6 Contributes to the Development of Experimental Colitis J. Immunol., April 15, 2009; 182(8): 5032 - 5040. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Joshi, D. J. Fong, S. R. Oak, G. Trujillo, K. R. Flaherty, F. J. Martinez, and C. M. Hogaboam Interleukin-17-mediated Immunopathogenesis in Experimental Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 705 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. R. Conti, F. Shen, N. Nayyar, E. Stocum, J. N. Sun, M. J. Lindemann, A. W. Ho, J. H. Hai, J. J. Yu, J. W. Jung, et al. Th17 cells and IL-17 receptor signaling are essential for mucosal host defense against oral candidiasis J. Exp. Med., February 16, 2009; 206(2): 299 - 311. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Kreindler, C. A. Bertrand, R. J. Lee, T. Karasic, S. Aujla, J. M. Pilewski, R. A. Frizzell, and J. K. Kolls Interleukin-17A induces bicarbonate secretion in normal human bronchial epithelial cells Am J Physiol Lung Cell Mol Physiol, February 1, 2009; 296(2): L257 - L266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Godinez, M. Raffatellu, H. Chu, T. A. Paixao, T. Haneda, R. L. Santos, C. L. Bevins, R. M. Tsolis, and A. J. Baumler Interleukin-23 Orchestrates Mucosal Responses to Salmonella enterica Serotype Typhimurium in the Intestine Infect. Immun., January 1, 2009; 77(1): 387 - 398. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Bugeon, L. M. Gardner, A. Rose, M. Gentle, and M. J. Dallman Cutting Edge: Notch Signaling Induces a Distinct Cytokine Profile in Dendritic Cells That Supports T Cell-Mediated Regulation and IL-2-Dependent IL-17 Production J. Immunol., December 15, 2008; 181(12): 8189 - 8193. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Jang, A. Uzelac, and P. Salgame Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection J. Leukoc. Biol., November 1, 2008; 84(5): 1264 - 1270. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Shibata, H. Yamada, R. Nakamura, X. Sun, M. Itsumi, and Y. Yoshikai Identification of CD25+ {gamma}{delta} T Cells As Fetal Thymus-Derived Naturally Occurring IL-17 Producers J. Immunol., November 1, 2008; 181(9): 5940 - 5947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. W. Quinn, N. A. Sims, H. Saleh, D. Mirosa, K. Thompson, S. Bouralexis, E. C. Walker, T. J. Martin, and M. T. Gillespie IL-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and Is Required for the Maintenance of Bone Mass in Mice J. Immunol., October 15, 2008; 181(8): 5720 - 5729. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. N. Ajuebor, Y. Jin, G. L. Gremillion, R. M. Strieter, Q. Chen, and P. A. Adegboyega {gamma}{delta}T Cells Initiate Acute Inflammation and Injury in Adenovirus-Infected Liver via Cytokine-Chemokine Cross Talk J. Virol., October 1, 2008; 82(19): 9564 - 9576. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hamada, M. Umemura, T. Shiono, K. Tanaka, A. Yahagi, M. D. Begum, K. Oshiro, Y. Okamoto, H. Watanabe, K. Kawakami, et al. IL-17A Produced by {gamma}{delta} T Cells Plays a Critical Role in Innate Immunity against Listeria monocytogenes Infection in the Liver J. Immunol., September 1, 2008; 181(5): 3456 - 3463. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. M. Schulz, G. Kohler, C. Holscher, Y. Iwakura, and G. Alber IL-17A is produced by Th17, {gamma}{delta} T cells and other CD4- lymphocytes during infection with Salmonella enterica serovar Enteritidis and has a mild effect in bacterial clearance Int. Immunol., September 1, 2008; 20(9): 1129 - 1138. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Takahashi, I. Vanlaere, R. de Rycke, A. Cauwels, L. A.B Joosten, E. Lubberts, W. B. van den Berg, and C. Libert IL-17 produced by Paneth cells drives TNF-induced shock J. Exp. Med., August 4, 2008; 205(8): 1755 - 1761. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. R. Lees, Y. Iwakura, and J. H. Russell Host T Cells Are the Main Producers of IL-17 within the Central Nervous System during Initiation of Experimental Autoimmune Encephalomyelitis Induced by Adoptive Transfer of Th1 Cell Lines J. Immunol., June 15, 2008; 180(12): 8066 - 8072. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Li and C.-Y. Wu CD4+CD25+ Treg cells inhibit human memory {gamma}{delta} T cells to produce IFN-{gamma} in response to M tuberculosis antigen ESAT-6 Blood, June 15, 2008; 111(12): 5629 - 5636. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Lochner, L. Peduto, M. Cherrier, S. Sawa, F. Langa, R. Varona, D. Riethmacher, M. Si-Tahar, J. P. Di Santo, and G. Eberl In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ ROR{gamma}t+ T cells J. Exp. Med., June 9, 2008; 205(6): 1381 - 1393. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K Dheda, J-S Chang, S Lala, J F Huggett, A Zumla, and G A W Rook Gene expression of IL17 and IL23 in the lungs of patients with active tuberculosis Thorax, June 1, 2008; 63(6): 566 - 568. [Full Text] [PDF]
|
|
|
|
|
|
X. O. Yang, S. H. Chang, H. Park, R. Nurieva, B. Shah, L. Acero, Y.-H. Wang, K. S. Schluns, R. R. Broaddus, Z. Zhu, et al. Regulation of inflammatory responses by IL-17F J. Exp. Med., May 12, 2008; 205(5): 1063 - 1075. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Romani, T. Zelante, A. De Luca, F. Fallarino, and P. Puccetti IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi J. Immunol., April 15, 2008; 180(8): 5157 - 5162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Scriba, B. Kalsdorf, D.-A. Abrahams, F. Isaacs, J. Hofmeister, G. Black, H. Y. Hassan, R. J. Wilkinson, G. Walzl, S. J. Gelderbloem, et al. Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response J. Immunol., February 1, 2008; 180(3): 1962 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Smith, A. Zarbock, M. A. Stark, T. L. Burcin, A. C. Bruce, P. Foley, and K. Ley IL-23 Is Required for Neutrophil Homeostasis in Normal and Neutrophilic Mice J. Immunol., December 15, 2007; 179(12): 8274 - 8279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. L. Roark, J. D. French, M. A. Taylor, A. M. Bendele, W. K. Born, and R. L. O'Brien Exacerbation of Collagen-Induced Arthritis by Oligoclonal, IL-17-Producing {gamma}{delta} T Cells J. Immunol., October 15, 2007; 179(8): 5576 - 5583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Linden A Role for the Cytoplasmic Adaptor Protein Act1 in Mediating IL-17 Signaling Sci. Signal., August 7, 2007; 2007(398): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Sato, T. Aranami, and T. Yamamura Cutting Edge: Human Th17 Cells Are Identified as Bearing CCR2+CCR5- Phenotype J. Immunol., June 15, 2007; 178(12): 7525 - 7529. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Maitra, F. Shen, W. Hanel, K. Mossman, J. Tocker, D. Swart, and S. L. Gaffen Distinct functional motifs within the IL-17 receptor regulate signal transduction and target gene expression PNAS, May 1, 2007; 104(18): 7506 - 7511. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
