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CUTTING EDGE |
Expression and Memory CD8 T Cell Development1
Department of Immunology, Center for Integrative Immunology and Vaccine Research, University of Connecticut Health Center, Farmington, CT 06030
Expression of IL-7R
on a subset of Ag-specific effector CD8 T cells is believed to identify memory cell precursors. However, whether IL-7 regulates IL-7R expression in vivo and is responsible for selective survival of IL-7R+ effector cells is unknown. Our results show that in the absence of IL-7, IL-7R expression was extinguished on the majority of CD8 T cells responding to virus infection, sustained on a subset of effector cells transitioning to memory, and expressed at high levels by memory cells. Additionally, an IL-7-deficient environment was capable of supporting bcl-2 up-regulation and memory cell development in response to virus infection. Thus, IL-7R regulation occurs independently of IL-7 in responding CD8 T cells, indicating that CD8 memory T cell precursors are not selected by IL-7/IL-7R interactions.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by National Institutes of Health (NIH) Grants AI41576, DK5260, and AI51583 (to L.L.). K.D.K. was supported by an NIH postdoctoral fellowship (AI053970).
2 Current address: Department of Cellular Biology, University of Georgia, Athens, GA 30602.
3 Address correspondence and reprint requests to Dr. Leo Lefrançois, Department of Immunology, University of Connecticut Health Center, M/C 1319, 263 Farmington Avenue, Farmington, CT 06030-1319. E-mail address: llefranc{at}neuron.uchc.edu
4 Abbreviations used in this paper: DC, dendritic cell; VSV, vesicular stomatitis virus; VSV-OVA, VSV expressing OVA; LCMV, lymphocytic choriomeningitis virus; TSLP, thymic stromal lymphopoietin.
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