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BRIEF REVIEWS |
Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111
CD5+ B cells have attracted considerable interest because of their association with self-reactivity, autoimmunity, and leukemia. In mice, CD5+ B cells are readily generated from fetal/neonatal precursors, but inefficiently from precursors in adult. One model proposed to explain this difference is that their production occurs through a distinctive developmental process, termed B-1, that enriches pre-B cells with novel germline VDJs and that requires positive selection of newly formed B cells by self-Ag. In contrast, follicular B cells are generated throughout adult life in a developmental process termed B-2, selecting VDJs that pair well with surrogate L chain, and whose maturation appears relatively independent of antigenic selection. In the present study, I focus on processes that shape the repertoire of mouse CD5+ B cells, describing the differences between B-1 and B-2 development, and propose a model encompassing both in the generation of functional B cell subpopulations.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was done with support from National Institutes of Health Grants AI26782 and AI40946.
2 Address correspondence and reprint requests to Division of Basic Sciences, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111. E-mail address: rr_hardy{at}fccc.edu
3 Abbreviations used in this paper: TSLP, thymic stromal-derived lymphopoietin; MZ, marginal zone; SLC, surrogate light chain; HEL, hen egg white lysozyme; ATA, anti-thymocyte/Thy-1 autoantibody; PtC, phosphatidylcholine.
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