|
|
||||||||
CUTTING EDGE |
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110
Abs against citrullinated proteins are present in patients with rheumatoid arthritis. In this study, we describe a unique cohort of T cells that selectively responded to citrullinated variants of two epitopes of hen egg-white lysozyme, a major and a minor one, bound to the MHC molecule, I-Ak. In addition, we show that when given an intact, unmodified lysozyme protein, dendritic cells and peritoneal macrophages presented citrullinated peptides and stimulated modification-specific T cells. Thus, presentation of citrullinated-peptide-MHC complex is a feature of immune responses to protein Ags.
This article has been cited by other articles:
![]() |
A. Beltrami, M. Rossmann, M. T. Fiorillo, F. Paladini, R. Sorrentino, W. Saenger, P. Kumar, A. Ziegler, and B. Uchanska-Ziegler Citrullination-dependent Differential Presentation of a Self-peptide by HLA-B27 Subtypes J. Biol. Chem., October 3, 2008; 283(40): 27189 - 27199. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |