| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
Regulates the Induction and Expansion of IL-17-Producing CD4 T Cells during Mycobacterial Infection1
* Life and Health Sciences Research Institute, School of Health Sciences, University of Minho, Braga, Portugal; and
Trudeau Institute, Saranac Lake, NY 12983
T cell responses are important to the control of infection but are deleterious if not regulated. IFN-
-deficient mice infected with mycobacteria exhibit enhanced accumulation of activated effector T cells and neutrophils within granulomatous lesions. These cells do not control bacterial growth and compromise the integrity of the infected tissue. We show that IFN--deficient mice have increased numbers of IL-17-producing T cells following infection with Mycobacterium bovis bacille Calmette Guérin. Furthermore, exogenous IFN- increases IL-12 and decreases IL-23 production by bacille Calmette Guérin-infected bone marrow-derived dendritic cells and reduces the frequency of IL-17-producing T cells induced by these bone marrow-derived dendritic cells. These data support the hypothesis that, during mycobacterial infection, both IFN-- and IL-17-producing T cells are induced, but that IFN- serves to limit the IL-17-producing T cell population. This counterregulation pathway may be an important factor in limiting mycobacterially associated immune-mediated pathology.
This article has been cited by other articles:
|
|
 |
|
  G. Murugaiyan, A. Mittal, R. Lopez-Diego, L. M. Maier, D. E. Anderson, and H. L. Weiner IL-27 Is a Key Regulator of IL-10 and IL-17 Production by Human CD4+ T Cells J. Immunol., August 15, 2009; 183(4): 2435 - 2443. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cui, H. Shao, C. Lan, H. Nian, R. L. O'Brien, W. K. Born, H. J. Kaplan, and D. Sun Major Role of {gamma}{delta} T Cells in the Generation of IL-17+ Uveitogenic T Cells J. Immunol., July 1, 2009; 183(1): 560 - 567. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Kish, X. Li, and R. L. Fairchild CD8 T Cells Producing IL-17 and IFN-{gamma} Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge J. Immunol., May 15, 2009; 182(10): 5949 - 5959. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Guo, D. Cobb, and R. B. Smeltz T-bet Inhibits the In Vivo Differentiation of Parasite-Specific CD4+ Th17 Cells in a T Cell-Intrinsic Manner J. Immunol., May 15, 2009; 182(10): 6179 - 6186. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. K. Hoyer, W. F. Kuswanto, E. Gallo, and A. K. Abbas Distinct roles of helper T-cell subsets in a systemic autoimmune disease Blood, January 8, 2009; 113(2): 389 - 395. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Lee, E. K. Reinke, A. L. Zozulya, M. Sandor, and Z. Fabry Mycobacterium bovis Bacille Calmette-Guerin Infection in the CNS Suppresses Experimental Autoimmune Encephalomyelitis and Th17 Responses in an IFN-{gamma}-Independent Manner J. Immunol., November 1, 2008; 181(9): 6201 - 6212. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Burrell, K. Csencsits, G. Lu, S. Grabauskiene, and D. K. Bishop CD8+ Th17 Mediate Costimulation Blockade-Resistant Allograft Rejection in T-bet-Deficient Mice J. Immunol., September 15, 2008; 181(6): 3906 - 3914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. Mauermann, J. Burian, C. von Garnier, S. Dirnhofer, D. Germano, C. Schuett, M. Tamm, R. Bingisser, U. Eriksson, and L. Hunziker Interferon-{gamma} Regulates Idiopathic Pneumonia Syndrome, a Th17+CD4+ T-Cell-mediated Graft-versus-Host Disease Am. J. Respir. Crit. Care Med., August 15, 2008; 178(4): 379 - 388. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Doodes, Y. Cao, K. M. Hamel, Y. Wang, B. Farkas, Y. Iwakura, and A. Finnegan Development of Proteoglycan-Induced Arthritis Is Independent of IL-17 J. Immunol., July 1, 2008; 181(1): 329 - 337. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Romani, T. Zelante, A. De Luca, F. Fallarino, and P. Puccetti IL-17 and Therapeutic Kynurenines in Pathogenic Inflammation to Fungi J. Immunol., April 15, 2008; 180(8): 5157 - 5162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. J. Scriba, B. Kalsdorf, D.-A. Abrahams, F. Isaacs, J. Hofmeister, G. Black, H. Y. Hassan, R. J. Wilkinson, G. Walzl, S. J. Gelderbloem, et al. Distinct, Specific IL-17- and IL-22-Producing CD4+ T Cell Subsets Contribute to the Human Anti-Mycobacterial Immune Response J. Immunol., February 1, 2008; 180(3): 1962 - 1970. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Cao, P. D. Doodes, T. T. Glant, and A. Finnegan IL-27 Induces a Th1 Immune Response and Susceptibility to Experimental Arthritis J. Immunol., January 15, 2008; 180(2): 922 - 930. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Niess, F. Leithauser, G. Adler, and J. Reimann Commensal Gut Flora Drives the Expansion of Proinflammatory CD4 T Cells in the Colonic Lamina Propria under Normal and Inflammatory Conditions J. Immunol., January 1, 2008; 180(1): 559 - 568. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. Xin, Y. Li, and L. Soong Role of Interleukin-1{beta} in Activating the CD11chigh CD45RB Dendritic Cell Subset and Priming Leishmania amazonensis- Specific CD4+ T Cells In Vitro and In Vivo Infect. Immun., October 1, 2007; 75(10): 5018 - 5026. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kimura, T. Naka, and T. Kishimoto IL-6-dependent and -independent pathways in the development of interleukin 17-producing T helper cells PNAS, July 17, 2007; 104(29): 12099 - 12104. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. F. Sheibanie, J.-H. Yen, T. Khayrullina, F. Emig, M. Zhang, R. Tuma, and D. Ganea The Proinflammatory Effect of Prostaglandin E2 in Experimental Inflammatory Bowel Disease Is Mediated through the IL-23->IL-17 Axis J. Immunol., June 15, 2007; 178(12): 8138 - 8147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. M. Wozniak, A. A. Ryan, and W. J. Britton Interleukin-23 Restores Immunity to Mycobacterium tuberculosis Infection in IL-12p40-Deficient Mice and Is Not Required for the Development of IL-17-Secreting T Cell Responses J. Immunol., December 15, 2006; 177(12): 8684 - 8692. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. A. Chackerian, S.-J. Chen, S. J. Brodie, J. D. Mattson, T. K. McClanahan, R. A. Kastelein, and E. P. Bowman Neutralization or Absence of the Interleukin-23 Pathway Does Not Compromise Immunity to Mycobacterial Infection Infect. Immun., November 1, 2006; 74(11): 6092 - 6099. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
