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Functional Specialization of Memory Th Cells Revealed by Expression of Integrin CD49b¹

George Kassiotis^2,*, David Gray, Ziba Kiafard, Jörg Zwirner and Brigitta Stockinger^3,*

^* Division of Molecular Immunology, National Institute for Medical Research, London, United Kingdom; Institute of Cell, Animal and Population Biology, University of Edinburgh, Ashworth Laboratories, Edinburgh, United Kingdom; and Department of Immunology, University of Göttingen, Göttingen, Germany

Infection or immunization induces heterogeneous memory T cell subsets, but their origin and protective value against infection are unclear. In this study, we report the functional characterization of two memory Th subsets, defined by expression of integrin CD49b. Stable CD49b expression is induced in up to one-half of all memory Th cells. More importantly, the CD49b^– and CD49b⁺ subsets display distinct helper activities, typified by the production of IL-10 and TNF-, respectively. Although the inflammatory properties of the CD49b⁺ subset are protective against intracellular bacterial infection, they are associated with immunopathology in acute viral infection. Modulation of the CD49b-defined memory Th subsets may provide infection type-specific interventions, where either enhancement of the inflammatory response or reduction of immunopathology is essential.

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