HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Masopust, D. Articles by Ahmed, R. Search for Related Content PubMed PubMed Citation Articles by Masopust, D. Articles by Ahmed, R.

Stimulation History Dictates Memory CD8 T Cell Phenotype: Implications for Prime-Boost Vaccination¹

Emory Vaccine Center and Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, GA, 30322

Heterologous prime-boost vaccination results in increased frequencies of memory T cells. Although these quantitative effects of reexposure to Ag are well documented, little is known about the impact of boosting on the functional qualities of memory T cells. To address this critical issue, we have used three different types of immunization regimens and examined how boosting effects the function and anatomic location of memory CD8 T cells. We found that memory T cell phenotype differed substantially depending on the number of immunizations and that secondary and tertiary responses resulted in the generation of memory CD8 T cells that retained effector-like properties and showed preferential accumulation in nonlymphoid tissues. These results show that memory differentiation is coupled to the history of Ag experience and that prime-boost vaccination strategies have important consequences on memory CD8 T cell quality and surveillance within mucosal tissues.

This article has been cited by other articles:

				N. Tatsis, M. O. Lasaro, S.-W. Lin, Z. Q. Xiang, D. Zhou, L. DiMenna, H. Li, A. Bian, S. Abdulla, Y. Li, et al. Adenovirus Vector-Induced Immune Responses in Nonhuman Primates: Responses to Prime Boost Regimens J. Immunol., May 15, 2009; 182(10): 6587 - 6599. [Abstract] [Full Text] [PDF]

				M. P. Rubinstein, N. A. Lind, J. F. Purton, P. Filippou, J. A. Best, P. A. McGhee, C. D. Surh, and A. W. Goldrath IL-7 and IL-15 differentially regulate CD8+ T-cell subsets during contraction of the immune response Blood, November 1, 2008; 112(9): 3704 - 3712. [Abstract] [Full Text] [PDF]

				M. Prlic and M. J. Bevan Exploring regulatory mechanisms of CD8+ T cell contraction PNAS, October 28, 2008; 105(43): 16689 - 16694. [Abstract] [Full Text] [PDF]

				Y. Sun, S. Santra, J. E. Schmitz, M. Roederer, and N. L. Letvin Magnitude and Quality of Vaccine-Elicited T-Cell Responses in the Control of Immunodeficiency Virus Replication in Rhesus Monkeys J. Virol., September 1, 2008; 82(17): 8812 - 8819. [Abstract] [Full Text] [PDF]

				E. B. Walker, D. Haley, U. Petrausch, K. Floyd, W. Miller, N. Sanjuan, G. Alvord, B. A. Fox, and W. J. Urba Phenotype and Functional Characterization of Long-term gp100-Specific Memory CD8+ T Cells in Disease-Free Melanoma Patients Before and After Boosting Immunization Clin. Cancer Res., August 15, 2008; 14(16): 5270 - 5283. [Abstract] [Full Text] [PDF]

				P. A. Swanson II, C. D. Pack, A. Hadley, C.-R. Wang, I. Stroynowski, P. E. Jensen, and A. E. Lukacher An MHC class Ib-restricted CD8 T cell response confers antiviral immunity J. Exp. Med., July 7, 2008; 205(7): 1647 - 1657. [Abstract] [Full Text] [PDF]

				K. Kedzierska, V. Venturi, S. A. Valkenburg, M. P. Davenport, S. J. Turner, and P. C. Doherty Homogenization of TCR Repertoires within Secondary CD62Lhigh and CD62Llow Virus-Specific CD8+ T Cell Populations J. Immunol., June 15, 2008; 180(12): 7938 - 7947. [Abstract] [Full Text] [PDF]

				C. A. Shaw and M. N. Starnbach Antigen Delivered by Anthrax Lethal Toxin Induces the Development of Memory CD8+ T Cells That Can Be Rapidly Boosted and Display Effector Functions Infect. Immun., March 1, 2008; 76(3): 1214 - 1222. [Abstract] [Full Text] [PDF]

				P. J. Holst, M. R. Sorensen, C. M. Mandrup Jensen, C. Orskov, A. R. Thomsen, and J. P. Christensen MHC Class II-Associated Invariant Chain Linkage of Antigen Dramatically Improves Cell-Mediated Immunity Induced by Adenovirus Vaccines J. Immunol., March 1, 2008; 180(5): 3339 - 3346. [Abstract] [Full Text] [PDF]

				Z. Li, M. Zhang, C. Zhou, X. Zhao, N. Iijima, and F. R. Frankel Novel Vaccination Protocol with Two Live Mucosal Vectors Elicits Strong Cell-Mediated Immunity in the Vagina and Protects against Vaginal Virus Challenge J. Immunol., February 15, 2008; 180(4): 2504 - 2513. [Abstract] [Full Text] [PDF]

				A.-H. Hovav, M. W. Panas, C. E. Osuna, M. J. Cayabyab, P. Autissier, and N. L. Letvin The Impact of a Boosting Immunogen on the Differentiation of Secondary Memory CD8+ T Cells J. Virol., December 1, 2007; 81(23): 12793 - 12802. [Abstract] [Full Text] [PDF]

				S. Sarkar, V. Teichgraber, V. Kalia, A. Polley, D. Masopust, L. E. Harrington, R. Ahmed, and E. J. Wherry Strength of Stimulus and Clonal Competition Impact the Rate of Memory CD8 T Cell Differentiation J. Immunol., November 15, 2007; 179(10): 6704 - 6714. [Abstract] [Full Text] [PDF]

				V. V. Ganusov Discriminating between Different Pathways of Memory CD8+ T Cell Differentiation J. Immunol., October 15, 2007; 179(8): 5006 - 5013. [Abstract] [Full Text] [PDF]

				N. Tatsis, J. C. Fitzgerald, A. Reyes-Sandoval, K. C. Harris-McCoy, S. E. Hensley, D. Zhou, S.-W. Lin, A. Bian, Z. Q. Xiang, A. Iparraguirre, et al. Adenoviral vectors persist in vivo and maintain activated CD8+ T cells: implications for their use as vaccines Blood, September 15, 2007; 110(6): 1916 - 1923. [Abstract] [Full Text] [PDF]

				S. Schwartzkopff, C. Grundemann, O. Schweier, S. Rosshart, K. E. Karjalainen, K.-F. Becker, and H. Pircher Tumor-Associated E-Cadherin Mutations Affect Binding to the Killer Cell Lectin-Like Receptor G1 in Humans J. Immunol., July 15, 2007; 179(2): 1022 - 1029. [Abstract] [Full Text] [PDF]

				A. L. Marzo, H. Yagita, and L. Lefrancois Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells J. Immunol., July 1, 2007; 179(1): 36 - 40. [Abstract] [Full Text] [PDF]

				V. P. Badovinac and J. T. Harty Manipulating the Rate of Memory CD8+ T Cell Generation after Acute Infection J. Immunol., July 1, 2007; 179(1): 53 - 63. [Abstract] [Full Text] [PDF]

				T. I. Naslund, C. Uyttenhove, E. K. L. Nordstrom, D. Colau, G. Warnier, M. Jondal, B. J. Van den Eynde, and P. Liljestrom Comparative Prime-Boost Vaccinations Using Semliki Forest Virus, Adenovirus, and ALVAC Vectors Demonstrate Differences in the Generation of a Protective Central Memory CTL Response against the P815 Tumor J. Immunol., June 1, 2007; 178(11): 6761 - 6769. [Abstract] [Full Text] [PDF]

				N. P. Andrews, C. D. Pack, V. Vezys, G. N. Barber, and A. E. Lukacher Early Virus-Associated Bystander Events Affect the Fitness of the CD8 T Cell Response to Persistent Virus Infection J. Immunol., June 1, 2007; 178(11): 7267 - 7275. [Abstract] [Full Text] [PDF]

				A. Peixoto, C. Evaristo, I. Munitic, M. Monteiro, A. Charbit, B. Rocha, and H. Veiga-Fernandes CD8 single-cell gene coexpression reveals three different effector types present at distinct phases of the immune response J. Exp. Med., May 14, 2007; 204(5): 1193 - 1205. [Abstract] [Full Text] [PDF]

				G. Arrode, R. Hegde, A. Mani, Y. Jin, Y. Chebloune, and O. Narayan Phenotypic and Functional Analysis of Immune CD8+ T Cell Responses Induced by a Single Injection of a HIV DNA Vaccine in Mice J. Immunol., February 15, 2007; 178(4): 2318 - 2327. [Abstract] [Full Text] [PDF]

				M. Kurachi, K. Kakimi, S. Ueha, and K. Matsushima Maintenance of memory CD8+ T cell diversity and proliferative potential by a primary response upon re-challenge Int. Immunol., January 1, 2007; 19(1): 105 - 115. [Abstract] [Full Text] [PDF]