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The Journal of Immunology, 2006, 177: 769-775.
Copyright © 2006 by The American Association of Immunologists

BRIEF REVIEWS

CD1d Ligands: The Good, the Bad, and the Ugly1

Randy R. Brutkiewicz2

Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202; and The Walther Oncology Center, Walther Cancer Institute, Indianapolis, IN 46208

The MHC class I-like CD1d glycoprotein is a member of the CD1 family of Ag-presenting molecules and is responsible for the selection of NKT cells. A number of ligands that can be presented by CD1d to NKT or other CD1d-restricted T cells have been identified. These include glycolipids from a marine sponge, bacterial glycolipids, normal endogenous glycolipids, tumor-derived phospholipids and glycolipids, and nonlipidic molecules. The presentation of many of these molecules can have immunopotentiating effects, such as serving as an adjuvant against malaria or resulting in a more rapid clearance of certain virus infections. They can also be protective in autoimmune diseases or cancer or can be deleterious. This review will highlight these ligands in a discussion of their potential use against (and role in the pathogenesis of) these diseases.




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