The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lartigue, A.
Right arrow Articles by Musette, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lartigue, A.
Right arrow Articles by Musette, P.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Compound via MeSH
*Substance via MeSH
The Journal of Immunology, 2006, 177: 1349-1354.
Copyright © 2006 by The American Association of Immunologists

Role of TLR9 in Anti-Nucleosome and Anti-DNA Antibody Production in lpr Mutation-Induced Murine Lupus1

Aurelia Lartigue*, Philippe Courville*,{dagger}, Isabelle Auquit*, Arnaud François{dagger}, Christophe Arnoult*, Francois Tron*,{ddagger}, Daniele Gilbert*,{ddagger} and Philippe Musette2,*,§

* Institut National de la Santé et de la Recherche Médicale Unité 519 and Institut Fédératif de Recherche Multidisciplinaire sur les Peptides, Faculté de Médecine et Pharmacie, Rouen, France; and {dagger} Laboratoire d’Anatomie-Pathologique, {ddagger} Laboratoire d’Immunopathologie Clinique et Expérimentale, and § Service de Dermatologie, Centre Hospitalier Universitaire Charles Nicolle, Rouen, France

Systemic lupus erythematosus is characterized by the production of autoantibodies directed against nuclear Ags, including nucleosome and DNA. TLR9 is thought to play a role in the production of these autoantibodies through the capacity of nuclear immunogenic particles to interact both with BCR and TLR9. To determine the role of TLR9 in SLE, C57BL/6-lpr/lpr-TLR9–/– and TLR9+/+ mice were analyzed. The abrogation of TLR9 totally impaired the production of anti-nucleosome Abs, whereas no difference was observed in the frequency of anti-dsDNA autoantibodies whose titer was strikingly higher in TLR9–/– mice. In addition a higher rate of mesangial proliferation was observed in the kidney of TLR9-deficient animals. These results indicate that in C57BL/6-lpr/lpr mice, TLR9 is absolutely required for the anti-nucleosome Ab response but not for anti-dsDNA Ab production which is involved in mesangial proliferation.




This article has been cited by other articles:


Home page
J. Immunol.Home page
A. Lartigue, N. Colliou, S. Calbo, A. Francois, S. Jacquot, C. Arnoult, F. Tron, D. Gilbert, and P. Musette
Critical Role of TLR2 and TLR4 in Autoantibody Production and Glomerulonephritis in lpr Mutation-Induced Mouse Lupus
J. Immunol., November 15, 2009; 183(10): 6207 - 6216.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
K. Hannestad and H. Scott
The MHC Haplotype H2b Converts Two Pure Nonlupus Mouse Strains to Producers of Antinuclear Antibodies
J. Immunol., September 1, 2009; 183(5): 3542 - 3550.
[Abstract] [Full Text] [PDF]


Home page
Proc. Natl. Acad. Sci. USAHome page
D. H. Kono, M. K. Haraldsson, B. R. Lawson, K. M. Pollard, Y. T. Koh, X. Du, C. N. Arnold, R. Baccala, G. J. Silverman, B. A. Beutler, et al.
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
PNAS, July 21, 2009; 106(29): 12061 - 12066.
[Abstract] [Full Text] [PDF]


Home page
JEMHome page
M. Lech, O. P. Kulkarni, S. Pfeiffer, E. Savarese, A. Krug, C. Garlanda, A. Mantovani, and H.-J. Anders
Tir8/Sigirr prevents murine lupus by suppressing the immunostimulatory effects of lupus autoantigens
J. Exp. Med., August 4, 2008; 205(8): 1879 - 1888.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
R. D. Pawar, A. Ramanjaneyulu, O. P. Kulkarni, M. Lech, S. Segerer, and H.-J. Anders
Inhibition of Toll-Like Receptor-7 (TLR-7) or TLR-7 plus TLR-9 Attenuates Glomerulonephritis and Lung Injury in Experimental Lupus
J. Am. Soc. Nephrol., June 1, 2007; 18(6): 1721 - 1731.
[Abstract] [Full Text] [PDF]


Home page
J. Am. Soc. Nephrol.Home page
K. D. Smith
Lupus Nephritis: Toll the Trigger!
J. Am. Soc. Nephrol., December 1, 2006; 17(12): 3273 - 3275.
[Full Text] [PDF]


Home page
J. Immunol.Home page
J. A. Deane and S. Bolland
Nucleic Acid-Sensing TLRs as Modifiers of Autoimmunity
J. Immunol., November 15, 2006; 177(10): 6573 - 6578.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
Z. Ma, F. Chen, M. P. Madaio, P. L. Cohen, and R. A. Eisenberg
Modulation of Autoimmunity by TLR9 in the Chronic Graft-vs-Host Model of Systemic Lupus Erythematosus
J. Immunol., November 15, 2006; 177(10): 7444 - 7450.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.