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* ChemoCentryx, Mountain View, CA 94043; and
Department of Microbiology and Immunology and the Cancer Research Institute, University of California San Francisco, San Francisco, CA 94143
To help understand the role of chemokines in NK cell trafficking, we determined the chemokine receptor profiles of three different human NK cell lines and freshly isolated primary human NK cells. The cell lines overlapped in their chemokine receptor profiles: CXCR3 and CXCR4 were expressed by all three lines, whereas CCR1, CCR4, CCR6, CCR7, and CX3CR1 were expressed by only one or two of the lines, and no other chemokine receptors were detected. Freshly isolated primary NK cells were found to express CXCR1, CXCR3, and CXCR4, and to contain subsets expressing CCR1, CCR4, CCR5, CCR6, CCR7, CCR9, CXCR5, and CXCR6. With the exception of CCR4, these chemokine receptors were expressed at higher percentages by CD56bright NK cells than by CD56dim NK cells. In particular, CCR7 was expressed by almost all CD56bright NK cells but was not detected on CD56dim NK cells. CCR9 and CXCR6 have not been described previously on primary NK cells. These results indicate that within both the CD56bright and CD56dim NK cell populations, subsets with the capacity for differential trafficking programs exist, which likely influence their functions in innate and adaptive immunity.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported in part by National Institutes of Health Grants AI068129 and AI056690. L.L.L. is an American Cancer Society Research Professor.
2 Address correspondence and reprint requests to Dr. Robert Berahovich, ChemoCentryx, 850 Maude Avenue, Mountain View, CA 94043. E-mail address: rberahovich{at}chemocentryx.com
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