| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
Department of Dermatology, University of Alabama at Birmingham, Birmingham, AL 35294
Allergen-induced contact hypersensitivity (CHS) is a T cell-mediated delayed-type immune response which has been considered to be primarily mediated by CD8+ T cytotoxic type I (Tc1) cells. IFN-
, the prototype Tc1 (Th1) cytokine, has been implicated as the primary inflammatory cytokine for CHS. In this study, we demonstrate that neutralization of IL-17 rather than IFN- suppresses the elicitation of CHS. The suppression does not result from inhibition of the proliferation of allergen-activated T cells. Allergen sensitization induces the development of distinct CD8+ T cell subpopulations that produce IFN- or IL-17. Although CD8+ IL-17-producing cells are stimulated by IL-23, they are inhibited by IL-12, a prototypical stimulator of IFN--producing Tc1 cells. This indicates that CD8+ IL-17-producing cells are distinct from Tc1 cells and are important in effector functions at the elicitation of CHS. These studies provide insights into a novel mechanism for CHS.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by Grant Number AR46256 from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (to. H.X). This investigation was conducted in a facility constructed with support from Research Facilities Improvement Program Grant No. C06 RR 15490 from the National Center for Research Resources, National Institutes of Health.
2 Address correspondence and reprint requests to Dr. Hui Xu, Department of Dermatology, University of Alabama at Birmingham, VH566B, 1670 University Boulevard, Birmingham, AL 35294. E-mail address: xuhui{at}uab.edu
3 Abbreviations used in this paper: CHS, contact hypersensitivity; Tc1, T cytotoxic type I; DNFB, dinitrofluorobenzene; DNBS, dinitrobenzenesulfonic acid, sodium salt; DC, dendritic cell; BM-DC, bone marrow-derived DC.
This article has been cited by other articles:
|
|
 |
|
  H.-R. Yen, T. J. Harris, S. Wada, J. F. Grosso, D. Getnet, M. V. Goldberg, K.-L. Liang, T. C. Bruno, K. J. Pyle, S.-L. Chan, et al. Tc17 CD8 T Cells: Functional Plasticity and Subset Diversity J. Immunol., December 1, 2009; 183(11): 7161 - 7168. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Smith, S. von Vietinghoff, M. A. Stark, A. Zarbock, J. M. Sanders, A. Duley, J. Rivera-Nieves, T. P. Bender, and K. Ley T-Lineage Cells Require the Thymus but Not V(D)J Recombination to Produce IL-17A and Regulate Granulopoiesis In Vivo J. Immunol., November 1, 2009; 183(9): 5685 - 5693. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Z. Igyarto, M. C. Jenison, J. C. Dudda, A. Roers, W. Muller, P. A. Koni, D. J. Campbell, M. J. Shlomchik, and D. H. Kaplan Langerhans Cells Suppress Contact Hypersensitivity Responses Via Cognate CD4 Interaction and Langerhans Cell-Derived IL-10 J. Immunol., October 15, 2009; 183(8): 5085 - 5093. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. He, L. Wu, H. K. Kim, H. Li, C. A. Elmets, and H. Xu IL-17 and IFN-{gamma} Mediate the Elicitation of Contact Hypersensitivity Responses by Different Mechanisms and Both Are Required for Optimal Responses J. Immunol., July 15, 2009; 183(2): 1463 - 1470. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. M. Curtis, S. S. Way, and C. B. Wilson IL-23 Promotes the Production of IL-17 by Antigen-Specific CD8 T Cells in the Absence of IL-12 and Type-I Interferons J. Immunol., July 1, 2009; 183(1): 381 - 387. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Jux, S. Kadow, and C. Esser Langerhans Cell Maturation and Contact Hypersensitivity Are Impaired in Aryl Hydrocarbon Receptor-Null Mice J. Immunol., June 1, 2009; 182(11): 6709 - 6717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. D. Kish, X. Li, and R. L. Fairchild CD8 T Cells Producing IL-17 and IFN-{gamma} Initiate the Innate Immune Response Required for Responses to Antigen Skin Challenge J. Immunol., May 15, 2009; 182(10): 5949 - 5959. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Rajagopalan, A. Y. Tilahun, Y. W. Asmann, and C. S. David Early gene expression changes induced by the bacterial superantigen staphylococcal enterotoxin B and its modulation by a proteasome inhibitor Physiol Genomics, May 13, 2009; 37(3): 279 - 293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Ciric, M. El-behi, R. Cabrera, G.-X. Zhang, and A. Rostami IL-23 Drives Pathogenic IL-17-Producing CD8+ T Cells J. Immunol., May 1, 2009; 182(9): 5296 - 5305. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. D. Joshi, D. J. Fong, S. R. Oak, G. Trujillo, K. R. Flaherty, F. J. Martinez, and C. M. Hogaboam Interleukin-17-mediated Immunopathogenesis in Experimental Hypersensitivity Pneumonitis Am. J. Respir. Crit. Care Med., April 15, 2009; 179(8): 705 - 716. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Kondo, H. Takata, F. Matsuki, and M. Takiguchi Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17 J. Immunol., February 15, 2009; 182(4): 1794 - 1798. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yusuf, T. H. Nasti, C.-M. Huang, B. S. Huber, T. Jaleel, H.-Y. Lin, H. Xu, and C. A. Elmets Heat Shock Proteins HSP27 and HSP70 Are Present in the Skin and Are Important Mediators of Allergic Contact Hypersensitivity J. Immunol., January 1, 2009; 182(1): 675 - 683. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. M. W. Quinn, N. A. Sims, H. Saleh, D. Mirosa, K. Thompson, S. Bouralexis, E. C. Walker, T. J. Martin, and M. T. Gillespie IL-23 Inhibits Osteoclastogenesis Indirectly through Lymphocytes and Is Required for the Maintenance of Bone Mass in Mice J. Immunol., October 15, 2008; 181(8): 5720 - 5729. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. E. Roses, S. Xu, M. Xu, U. Koldovsky, G. Koski, and B. J. Czerniecki Differential Production of IL-23 and IL-12 by Myeloid-Derived Dendritic Cells in Response to TLR Agonists J. Immunol., October 1, 2008; 181(7): 5120 - 5127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Wakasa-Morimoto, T. Toyosaki-Maeda, T. Matsutani, R. Yoshida, S. Nakamura-Kikuoka, M. Maeda-Tanimura, H. Yoshitomi, K. Hirota, M. Hashimoto, H. Masaki, et al. Arthritis and pneumonitis produced by the same T cell clones from mice with spontaneous autoimmune arthritis Int. Immunol., October 1, 2008; 20(10): 1331 - 1342. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. E. Burrell, K. Csencsits, G. Lu, S. Grabauskiene, and D. K. Bishop CD8+ Th17 Mediate Costimulation Blockade-Resistant Allograft Rejection in T-bet-Deficient Mice J. Immunol., September 15, 2008; 181(6): 3906 - 3914. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. F. Martin, J. C. Dudda, E. Bachtanian, A. Lembo, S. Liller, C. Durr, M. M. Heimesaat, S. Bereswill, G. Fejer, R. Vassileva, et al. Toll-like receptor and IL-12 signaling control susceptibility to contact hypersensitivity J. Exp. Med., September 1, 2008; 205(9): 2151 - 2162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J.-S. Nam, M. Terabe, M.-J. Kang, H. Chae, N. Voong, Y.-a. Yang, A. Laurence, A. Michalowska, M. Mamura, S. Lonning, et al. Transforming Growth Factor {beta} Subverts the Immune System into Directly Promoting Tumor Growth through Interleukin-17 Cancer Res., May 15, 2008; 68(10): 3915 - 3923. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yusuf, T. H. Nasti, S. K. Katiyar, M. K. Jacobs, M. D. Seibert, A. C. Ginsburg, L. Timares, H. Xu, and C. A. Elmets Antagonistic Roles of CD4+ and CD8+ T-Cells in 7,12-Dimethylbenz(a)anthracene Cutaneous Carcinogenesis Cancer Res., May 15, 2008; 68(10): 3924 - 3930. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Rana, S. N. Byrne, L. J. MacDonald, C. Y.-Y. Chan, and G. M. Halliday Ultraviolet B Suppresses Immunity by Inhibiting Effector and Memory T Cells Am. J. Pathol., April 1, 2008; 172(4): 993 - 1004. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. Yusuf, T. H. Nasti, J. A. Long, M. Naseemuddin, A. P. Lucas, H. Xu, and C. A. Elmets Protective Role of Toll-like Receptor 4 during the Initiation Stage of Cutaneous Chemical Carcinogenesis Cancer Res., January 15, 2008; 68(2): 615 - 622. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Linden A Role for the Cytoplasmic Adaptor Protein Act1 in Mediating IL-17 Signaling Sci. Signal., August 7, 2007; 2007(398): re4 - re4. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
