The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
 QUICK SEARCH:   [advanced]


     
 


This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Monari, C.
Right arrow Articles by Vecchiarelli, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Monari, C.
Right arrow Articles by Vecchiarelli, A.
The Journal of Immunology, 2006, 177: 6842-6851.
Copyright © 2006 by The American Association of Immunologists, Inc.

Microbial Immune Suppression Mediated by Direct Engagement of Inhibitory Fc Receptor1

Claudia Monari*, Thomas R. Kozel{dagger}, Francesca Paganelli*, Eva Pericolini*, Stefano Perito*, Francesco Bistoni*, Arturo Casadevall{ddagger} and Anna Vecchiarelli2,*

* Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy; {dagger} Department of Microbiology and Immunology, University of Nevada, Reno, NV 89557; and {ddagger} Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461

A microbial polysaccharide (glucuronoxylomannan (GXM)) exerts potent immunosuppression by direct engagement to immunoinhibitory receptor Fc{gamma}RIIB. Activation of Fc{gamma}RIIB by GXM leads to the recruitment and phosphorylation of SHIP that prevents I{kappa}B{alpha} activation. The Fc{gamma}RIIB blockade inhibits GXM-induced IL-10 production and induces TNF-{alpha} secretion. GXM quenches LPS-induced TNF-{alpha} release via Fc{gamma}RIIB. The addition of mAb to GXM reverses GXM-induced immunosuppression by shifting recognition from Fc{gamma}RIIB to Fc{gamma}RIIA. These findings indicate a novel mechanism by which microbial products can impair immune function through direct stimulation of an inhibitory receptor. Furthermore, our observations provide a new mechanism for the ability of specific Ab to reverse the immune inhibitory effects of certain microbial products.

The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.

1 This work was supported by the National Institute of Health AIDS Project No. 50 F.36, Basic Research Investment Funds Project No. RBLA03C9F4_006, Public Health Service Grant AI14209, and from the National Institute for Allergy and Infectious Diseases (to T.R.K.). A.C. is supported in part by Public Health Service Grant HL059842.

2 Address correspondence and reprint requests to Professor Anna Vecchiarelli, Microbiology Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. E-mail address: vecchiar{at}unipg.it

3 Abbreviations used in this paper: GXM, glucuronoxylomannan; MFI, mean fluorescence intensity; P-, phospho-; FLUOS, 5(6)-carboxyfluorescein-N-hydroxysuccinimide ester.




This article has been cited by other articles:


Home page
J. Immunol.Home page
M. H. Wenink, K. C. M. Santegoets, M. F. Roelofs, R. Huijbens, H. J. P. M. Koenen, R. van Beek, I. Joosten, F. Meyer-Wentrup, L. Mathsson, J. Ronnelid, et al.
The Inhibitory Fc{gamma}IIb Receptor Dampens TLR4-Mediated Immune Responses and Is Selectively Up-regulated on Dendritic Cells from Rheumatoid Arthritis Patients with Quiescent Disease
J. Immunol., October 1, 2009; 183(7): 4509 - 4520.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
C. Monari, S. Bevilacqua, M. Piccioni, E. Pericolini, S. Perito, M. Calvitti, F. Bistoni, T. R. Kozel, and A. Vecchiarelli
A Microbial Polysaccharide Reduces the Severity of Rheumatoid Arthritis by Influencing Th17 Differentiation and Proinflammatory Cytokines Production
J. Immunol., July 1, 2009; 183(1): 191 - 200.
[Abstract] [Full Text] [PDF]


Home page
J. Immunol.Home page
E. Pericolini, E. Gabrielli, E. Cenci, M. De Jesus, F. Bistoni, A. Casadevall, and A. Vecchiarelli
Involvement of Glycoreceptors in Galactoxylomannan-Induced T Cell Death
J. Immunol., May 15, 2009; 182(10): 6003 - 6010.
[Abstract] [Full Text] [PDF]


Home page
Int ImmunolHome page
L. S. Chiapello, J. L. Baronetti, A. P. Garro, M. F. Spesso, and D. T. Masih
Cryptococcus neoformans glucuronoxylomannan induces macrophage apoptosis mediated by nitric oxide in a caspase-independent pathway
Int. Immunol., December 1, 2008; 20(12): 1527 - 1541.
[Abstract] [Full Text] [PDF]


Home page
CVIHome page
K. Datta, A. Lees, and L.-a. Pirofski
Therapeutic Efficacy of a Conjugate Vaccine Containing a Peptide Mimotope of Cryptococcal Capsular Polysaccharide Glucuronoxylomannan
Clin. Vaccine Immunol., August 1, 2008; 15(8): 1176 - 1187.
[Abstract] [Full Text] [PDF]




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.