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* Institute of Immunology, Hannover Medical School, Hannover, Germany;
Institute for Laboratory Animal Science, Hannover Medical School, Hannover, Germany; and
Department of Medicine, McMaster University, Ontario, Canada
Besides Peyer’s patches, solitary intestinal lymphoid tissue (SILT) provides a structural platform to efficiently initiate immune responses in the murine small intestine. SILT consists of dynamic lymphoid aggregates that are heterogeneous in size and composition, ranging from small clusters of mostly lineage-negative cells known as cryptopatches to larger isolated lymphoid follicles rich in B cells. In this study, we report that in chemokine receptor CCR7-deficient mice SILT is enlarged, although unchanged in frequency and cellular composition compared with wild-type mice. This phenotype is conferred by bone marrow-derived cells and is independent of the presence of intestinal bacteria. Remarkably, particularly small-sized SILT predominates in germfree wild-type mice. Colonization of wild-type mice with commensal bacteria provokes an adjustment of the spectrum of SILT to that observed under specific pathogen-free conditions by the conversion of pre-existing lymphoid structures into larger-sized SILT. In conclusion, our findings establish that intestinal microbes influence the manifestation of gut-associated lymphoid tissues and identify CCR7 signaling as an endogeneous factor that controls this process.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by Deutsche Forschungsgemeinschaft Grants SFB621-A11 (to O.P.) and SFB621-Z1.
2 Address correspondence and reprint requests to Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School, Carl-Neuberg Strasse 1, 30625 Hannover, Germany. E-mail address: Pabst.Oliver{at}mh-hannover.de
3 Abbreviations used in this paper: PP, Peyer’s patch; CP, cryptopatch; DAPI, 4',6'-diamidino-2-phenylindole; DC, dendritic cell; ILF, isolated lymphoid follicle; LTIC, lymphoid tissue-inducer cell; SILT, solitary intestinal lymphoid tissue.
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