| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* School of Life Sciences and Biotechnology, Korea University, Seoul, Korea;
Laboratory of Immunology, College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Korea; and
Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea
NKT cells perform crucial roles in tumor surveillance, functioning as regulators of early host response. In this study, we have assessed the effects of NKT activation at the time of tumor Ag immunization, and have evaluated the contributions of CD4+ and CD8+ T cells in tumor rejection during adaptive immune response against live tumor cells. Our data indicate that CD4+ T cells play critical roles, not only in assisting CTL, but also in the orchestration of host response against the tumor. The CD4+ T cells were found to reject the transplanted tumor cells very efficiently under conditions in which the CTLs were removed either genetically, or via the action of anti-CD8 Ab in mice that had been immunized with tumor extracts and 
-galactosylceramide. Immunization resulted in an NKT cell-dependent antitumor adaptive immune response, which was associated with both CD4+ T cells and cytokine IFN-
.
The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked advertisement in accordance with 18 U.S.C. Section 1734 solely to indicate this fact.
1 This work was supported by a Rheumatism Research Center Grant (R11-2002-098-05005-0) from the Korea Science and Engineering Foundation.
2 Address correspondence and reprint requests to Dr. Se-Ho Park, School of Life Sciences and Biotechnology, Korea University, Anam-Dong, Sungbuk-Gu, Seoul 136-701, Korea. E-mail address: sehopark{at}korea.ac.kr
3 Abbreviations used in this paper: -GalCer, -galactosylceramide; DC, dendritic cell; WT, wild type; Veh, vehicle; StAv, streptavidin; SSC, side scatter; int, intermediate.
This article has been cited by other articles:
|
|
 |
|
  J. P. Driver, F. Scheuplein, Y.-G. Chen, A. E. Grier, S. B. Wilson, and D. V. Serreze Invariant Natural Killer T-Cell Control of Type 1 Diabetes: A Dendritic Cell Genetic Decision of a Silver Bullet or Russian Roulette Diabetes, February 1, 2010; 59(2): 423 - 432. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Hong, H. Lee, Y.-K. Park, J. Shin, S. Jung, H. Kim, S. Hong, and S.-H. Park Regulation of Secondary Antigen-Specific CD8+ T-Cell Responses by Natural Killer T Cells Cancer Res., May 15, 2009; 69(10): 4301 - 4308. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H.-J. Ko, J.-M. Lee, Y.-J. Kim, Y.-S. Kim, K.-A Lee, and C.-Y. Kang Immunosuppressive Myeloid-Derived Suppressor Cells Can Be Converted into Immunogenic APCs with the Help of Activated NKT Cells: An Alternative Cell-Based Antitumor Vaccine J. Immunol., February 15, 2009; 182(4): 1818 - 1828. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Y. Chung, H. Qin, C.-Y. Kang, S. Kim, L. W. Kwak, and C. Dong An NKT-mediated autologous vaccine generates CD4 T-cell dependent potent antilymphoma immunity Blood, September 15, 2007; 110(6): 2013 - 2019. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
