HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dhanji, S. Articles by Teh, H.-S. Search for Related Content PubMed PubMed Citation Articles by Dhanji, S. Articles by Teh, H.-S. Pubmed/NCBI databases Substance via MeSH

Self-Antigen Maintains the Innate Antibacterial Function of Self-Specific CD8 T Cells In Vivo¹

Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

Self-specific CD8 T cells, which are selected by high-affinity interactions with self-Ags, develop into a lineage distinct from conventional CD8 T cells. We have previously shown that these self-specific cells acquire phenotypic and functional similarities to cells of the innate immune system including the expression of functional receptors associated with NK cells. In this study, we show that these self-specific cells have the ability to produce large amounts of IFN- in response to infection with Listeria monocytogenes in a bystander fashion. The rapid production of IFN- is associated with a dramatic reduction in the number of viable bacteria at the peak of infection. Self-specific CD8 T cells provide only marginal innate protection in the absence of self-Ag; however, the presence of self-Ag dramatically increases their protective ability. Exposure to self-Ag is necessary for the maintenance of the memory phenotype and responsiveness to inflammatory cytokines such as IL-15. Significantly, self-specific CD8 T cells are also more efficient in the production of IFN- and TNF-, thus providing more cytokine-dependent protection against bacterial infection when compared with NK cells. These findings illustrate that self-reactive CD8 T cells can play an important innate function in the early defense against bacterial infection.

This article has been cited by other articles:

				X. Chen, J. J. Priatel, M. T. Chow, and H.-S. Teh Preferential Development of CD4 and CD8 T Regulatory Cells in RasGRP1-Deficient Mice J. Immunol., May 1, 2008; 180(9): 5973 - 5982. [Abstract] [Full Text] [PDF]

				A. Kosaka, D. Wakita, N. Matsubara, Y. Togashi, S.-I. Nishimura, H. Kitamura, and T. Nishimura AsialoGM1+CD8+ central memory-type T cells in unimmunized mice as novel immunomodulator of IFN-{gamma}-dependent type 1 immunity Int. Immunol., March 1, 2007; 19(3): 249 - 256. [Abstract] [Full Text] [PDF]

				M. T. Chow, S. Dhanji, J. Cross, P. Johnson, and H.-S. Teh H2-M3-Restricted T Cells Participate in the Priming of Antigen-Specific CD4+ T Cells J. Immunol., October 15, 2006; 177(8): 5098 - 5104. [Abstract] [Full Text] [PDF]