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The Journal of Immunology, 2006, 177: 11-16.
Copyright © 2006 by The American Association of Immunologists

BRIEF REVIEWS

Intracellular TLR Signaling: A Structural Perspective on Human Disease1

Michael V. Lasker2,*,{dagger} and Satish K. Nair*,{ddagger}

* Department of Biochemistry, {dagger} Medical Scholars Program, and {ddagger} Center for Biophysics and Computational Biology, University of Illinois, Urbana, IL 61801

TLRs are crucial sensors of microbial infection. Maintaining structural integrity of TLR signaling components is essential for subsequent immunological protection. Alterations to the structure of these signaling molecules are often associated with profound clinical outcomes and susceptibility to various infectious diseases. These changes in structure are sometimes the result of a single nucleotide polymorphism (SNP). Numerous SNPs have been found in components of the TLR signaling pathway. Recently, the medical consequences and effects on TLR signaling of several of these SNPs have been elucidated. In addition, there have been numerous structures solved that are important to our understanding of the TLR signaling pathway at the molecular level. The scope of this review is to tie together current structural, biochemical, and genetic information of TLR signaling.




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