HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in The JI Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Nicolson, K. S. Articles by Wraith, D. C. Search for Related Content PubMed PubMed Citation Articles by Nicolson, K. S. Articles by Wraith, D. C.

Antigen-Induced IL-10⁺ Regulatory T Cells Are Independent of CD25⁺ Regulatory Cells for Their Growth, Differentiation, and Function¹

Department of Cellular and Molecular Medicine, University of Bristol Medical School, Bristol, United Kingdom

Recent studies have emphasized the importance of T cells with regulatory/suppressor properties in controlling autoimmune diseases. A number of different types of regulatory T cells have been described with the best characterized being the CD25⁺ population. In addition, it has been shown that regulatory T cells can be induced by specific Ag administration. In this study, we investigate the relationship between peptide-induced, CD4⁺ regulatory T cells and naturally occurring CD4⁺CD25⁺ cells derived from the Tg4 TCR-transgenic mouse. Peptide-induced cells were FoxP3^– and responded to Ag by secreting IL-10, whereas CD25⁺ cells failed to secrete this cytokine. Both cell types were able to suppress the proliferation of naive lymphocytes in vitro although with distinct activation sensitivities. Depletion of CD25⁺ cells did not affect the suppressive properties of peptide-induced regulators. Furthermore, peptide-induced regulatory/suppressor T cells could be generated in RAG^–/–, TCR-transgenic mice that do not spontaneously generate CD25⁺ regulatory cells. These results demonstrate that these natural and induced regulatory cells fall into distinct subsets.

Related articles in The JI:

IN THIS ISSUE

The JI 2006 176: 5131-5132. [Full Text]  

This article has been cited by other articles:

				W. Hansen, A. M. Westendorf, S. Reinwald, D. Bruder, S. Deppenmeier, L. Groebe, M. Probst-Kepper, A. D. Gruber, R. Geffers, and J. Buer Chronic Antigen Stimulation In Vivo Induces a Distinct Population of Antigen-Specific Foxp3 CD25 Regulatory T Cells J. Immunol., December 15, 2007; 179(12): 8059 - 8068. [Abstract] [Full Text] [PDF]

				K. Gee, J. B. Angel, S. Mishra, M. A. Blahoianu, and A. Kumar IL-10 Regulation by HIV-Tat in Primary Human Monocytic Cells: Involvement of Calmodulin/Calmodulin-Dependent Protein Kinase-Activated p38 MAPK and Sp-1 and CREB-1 Transcription Factors J. Immunol., January 15, 2007; 178(2): 798 - 807. [Abstract] [Full Text] [PDF]