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Antigen-Induced IL-10⁺ Regulatory T Cells Are Independent of CD25⁺ Regulatory Cells for Their Growth, Differentiation, and Function¹

Department of Cellular and Molecular Medicine, University of Bristol Medical School, Bristol, United Kingdom

Recent studies have emphasized the importance of T cells with regulatory/suppressor properties in controlling autoimmune diseases. A number of different types of regulatory T cells have been described with the best characterized being the CD25⁺ population. In addition, it has been shown that regulatory T cells can be induced by specific Ag administration. In this study, we investigate the relationship between peptide-induced, CD4⁺ regulatory T cells and naturally occurring CD4⁺CD25⁺ cells derived from the Tg4 TCR-transgenic mouse. Peptide-induced cells were FoxP3^– and responded to Ag by secreting IL-10, whereas CD25⁺ cells failed to secrete this cytokine. Both cell types were able to suppress the proliferation of naive lymphocytes in vitro although with distinct activation sensitivities. Depletion of CD25⁺ cells did not affect the suppressive properties of peptide-induced regulators. Furthermore, peptide-induced regulatory/suppressor T cells could be generated in RAG^–/–, TCR-transgenic mice that do not spontaneously generate CD25⁺ regulatory cells. These results demonstrate that these natural and induced regulatory cells fall into distinct subsets.

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The JI 2006 176: 5131-5132. [Full Text]  

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