| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
* Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Freiburg, Germany; and
Department of Immunology, Paul Ehrlich Institute, Langen, Germany
The role of type I IFN signaling in CD8 T cells was analyzed in an adoptive transfer model using P14 TCR transgenic CD8 T cells specific for lymphocytic choriomeningitis virus (LCMV) but deficient in type I IFNR. In the present study, we demonstrate severe impairment in the capacity of P14 T cells lacking type I IFNR to expand in normal type I IFNR wild-type C57BL/6 hosts after LCMV infection. In contrast, following infection of recipient mice with recombinant vaccinia virus expressing LCMV glycoprotein, P14 T cell expansion was considerably less dependent on type I IFNR expression. Lack of type I IFNR expression by P14 T cells did not affect cell division after LCMV infection but interfered with clonal expansion. Thus, direct type I IFN signaling is essential for CD8 T cell survival in certain viral infections.
This article has been cited by other articles:
|
|
 |
|
  A. Pilz, W. Kratky, S. Stockinger, O. Simma, U. Kalinke, K. Lingnau, A. von Gabain, D. Stoiber, V. Sexl, T. Kolbe, et al. Dendritic Cells Require STAT-1 Phosphorylated at Its Transactivating Domain for the Induction of Peptide-Specific CTL J. Immunol., August 15, 2009; 183(4): 2286 - 2293. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Agarwal, A. Raghavan, S. L. Nandiwada, J. M. Curtsinger, P. R. Bohjanen, D. L. Mueller, and M. F. Mescher Gene Regulation and Chromatin Remodeling by IL-12 and Type I IFN in Programming for CD8 T Cell Effector Function and Memory J. Immunol., August 1, 2009; 183(3): 1695 - 1704. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. G. Sikora, N. Jaffarzad, Y. Hailemichael, A. Gelbard, S. W. Stonier, K. S. Schluns, L. Frasca, Y. Lou, C. Liu, H. A. Andersson, et al. IFN-{alpha} Enhances Peptide Vaccine-Induced CD8+ T Cell Numbers, Effector Function, and Antitumor Activity J. Immunol., June 15, 2009; 182(12): 7398 - 7407. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. McAleer, R. J. Rossi, and A. T. Vella Lipopolysaccharide Potentiates Effector T Cell Accumulation into Nonlymphoid Tissues through TRIF J. Immunol., May 1, 2009; 182(9): 5322 - 5330. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Xiao, K. A. Casey, S. C. Jameson, J. M. Curtsinger, and M. F. Mescher Programming for CD8 T Cell Memory Development Requires IL-12 or Type I IFN J. Immunol., March 1, 2009; 182(5): 2786 - 2794. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Bartholdy, J. E. Christensen, M. Grujic, J. P. Christensen, and A. R. Thomsen T-cell intrinsic expression of MyD88 is required for sustained expansion of the virus-specific CD8+ T-cell population in LCMV-infected mice J. Gen. Virol., February 1, 2009; 90(2): 423 - 431. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. A. Lang, L. Cervantes-Barragan, A. Verschoor, A. A. Navarini, M. Recher, M. Pellegrini, L. Flatz, A. Bergthaler, K. Honda, B. Ludewig, et al. Hematopoietic cell-derived interferon controls viral replication and virus-induced disease Blood, January 29, 2009; 113(5): 1045 - 1052. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervantes-Barragan, U. Kalinke, R. Zust, M. Konig, B. Reizis, C. Lopez-Macias, V. Thiel, and B. Ludewig Type I IFN-Mediated Protection of Macrophages and Dendritic Cells Secures Control of Murine Coronavirus Infection J. Immunol., January 15, 2009; 182(2): 1099 - 1106. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Salek-Ardakani, M. Moutaftsi, S. Crotty, A. Sette, and M. Croft OX40 Drives Protective Vaccinia Virus-Specific CD8 T Cells J. Immunol., December 1, 2008; 181(11): 7969 - 7976. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. C. Wilson, S. Matthews, and G. S. Yap IL-12 Signaling Drives CD8+ T Cell IFN-{gamma} Production and Differentiation of KLRG1+ Effector Subpopulations during Toxoplasma gondii Infection J. Immunol., May 1, 2008; 180(9): 5935 - 5945. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Kunz, K. Oberle, A. Sander, C. Bogdan, and U. Schleicher Lymphadenopathy in a Novel Mouse Model of Bartonella-Induced Cat Scratch Disease Results from Lymphocyte Immigration and Proliferation and Is Regulated by Interferon-{alpha}/{beta} Am. J. Pathol., April 1, 2008; 172(4): 1005 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Quigley, X. Huang, and Y. Yang STAT1 Signaling in CD8 T Cells Is Required for Their Clonal Expansion and Memory Formation Following Viral Infection In Vivo J. Immunol., February 15, 2008; 180(4): 2158 - 2164. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jung, H. Kato, Y. Kumagai, H. Kumar, T. Kawai, O. Takeuchi, and S. Akira Lymphocytoid Choriomeningitis Virus Activates Plasmacytoid Dendritic Cells and Induces a Cytotoxic T-Cell Response via MyD88 J. Virol., January 1, 2008; 82(1): 196 - 206. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. P. McAleer, D. J. Zammit, L. Lefrancois, R. J. Rossi, and A. T. Vella The Lipopolysaccharide Adjuvant Effect on T Cells Relies on Nonoverlapping Contributions from the MyD88 Pathway and CD11c+ Cells J. Immunol., November 15, 2007; 179(10): 6524 - 6535. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Wesley, M. S. Tessmer, C. Paget, F. Trottein, and L. Brossay A Y Chromosome-Linked Factor Impairs NK T Development J. Immunol., September 15, 2007; 179(6): 3480 - 3487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xiao, J. M. Curtsinger, M. Prlic, S. C. Jameson, and M. F. Mescher The CD8 T cell response to vaccinia virus exhibits site-dependent heterogeneity of functional responses Int. Immunol., June 1, 2007; 19(6): 733 - 743. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Hosmalin and P. Lebon Type I interferon production in HIV-infected patients J. Leukoc. Biol., November 1, 2006; 80(5): 984 - 993. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
