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The Journal of Immunology, 2006, 176: 4343-4351.
Copyright © 2006 by The American Association of Immunologists

Type I IFN Receptor Signals Directly Stimulate Local B Cells Early following Influenza Virus Infection1

Elizabeth S. Coro, W. L. William Chang and Nicole Baumgarth2

Center for Comparative Medicine, University of California, Davis, CA 95616

Rapidly developing Ab responses to influenza virus provide immune protection even during a primary infection. How these early B cell responses are regulated is incompletely understood. In this study, we show that the first direct stimulatory signal for local respiratory tract B cells during influenza virus infection is provided through the type I IFNR. IFNR-mediated signals were responsible for the influenza infection-induced local but not systemic up-regulation of CD69 and CD86 on virtually all lymph node B cells and for induction of a family of IFN-regulated genes within 48 h of infection. These direct IFNR-mediated signals were shown to affect both the magnitude and quality of the local virus-specific Ab response. Thus, ligand(s) of the type I IFNR are direct nonredundant early innate signals that regulate local antiviral B cell responses.




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