HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) A correction has been published Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Sud, D. Articles by Kirschner, D. E. Search for Related Content PubMed PubMed Citation Articles by Sud, D. Articles by Kirschner, D. E.

Contribution of CD8⁺ T Cells to Control of Mycobacterium tuberculosis Infection¹

Dhruv Sud^*,, Carolyn Bigbee, JoAnne L. Flynn and Denise E. Kirschner^2,*,

^* Department of Biomedical Engineering, College of Engineering, University of Michigan, Ann Arbor, MI 48109; Department of Molecular Genetics and Biochemistry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261; and Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109

Tuberculosis is the number one cause of death due to infectious disease in the world today. Understanding the dynamics of the immune response is crucial to elaborating differences between individuals who contain infection vs those who suffer active disease. Key cells in an adaptive immune response to intracellular pathogens include CD8⁺ T cells. Once stimulated, these cells provide a number of different effector functions, each aimed at clearing or containing the pathogen. To explore the role of CD8⁺ T cells in an integrative way, we synthesize both published and unpublished data to build and test a mathematical model of the immune response to Mycobacterium tuberculosis in the lung. The model is then used to perform a series of simulations mimicking experimental situations. Selective deletion of CD8⁺ T cell subsets suggests a differential contribution for CD8⁺ T cell effectors that are cytotoxic as compared with those that produce IFN-. We also determined the minimum levels of effector memory cells of each T cell subset (CD4⁺ and CD8⁺) in providing effective protection following vaccination.

This article has been cited by other articles:

				J. Andersson, A. Samarina, J. Fink, S. Rahman, and S. Grundstrom Impaired Expression of Perforin and Granulysin in CD8+ T Cells at the Site of Infection in Human Chronic Pulmonary Tuberculosis Infect. Immun., November 1, 2007; 75(11): 5210 - 5222. [Abstract] [Full Text] [PDF]

				W. W. Yew and C. C. Leung Update in Tuberculosis 2006 Am. J. Respir. Crit. Care Med., March 15, 2007; 175(6): 541 - 546. [Full Text] [PDF]