|
|
||||||||






* Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390;
Department of Biological Sciences, Allergan, Irvine, CA 92623; and
Department of Ophthalmology, Baylor College of Medicine, Houston, TX 77030
Chronic dry eye syndrome affects over 10 million people in the United States; it is associated with inflammation of the lacrimal gland (LG) and in some cases involves T cell infiltration of the conjunctiva. We demonstrate that environmental desiccating stress (DS) elicits T cell-mediated inflammation of the cornea, conjunctiva, and LG, but not other organs in mice. The lacrimal keratoconjunctivitis (LKC) was mediated by CD4+ T cells, which, when adoptively transferred to T cell-deficient nude mice, produced inflammation in the LG, cornea, and conjunctiva, but not in any other organ. Adoptively transferred CD4+ T cells produced LKC even though recipients were not exposed to DS. LKC was exacerbated in euthymic mice depleted of CD4+CD25+forkhead/winged helix transcription factor+ regulatory T cells. The results suggest that DS exposes shared epitopes in the cornea, conjunctiva, and LG that induce pathogenic CD4+ T cells that produce LKC, which under normal circumstances is restrained by CD4+CD25+forkhead/winged helix transcription factor+ regulatory T cells.
Related articles in The JI:
This article has been cited by other articles:
![]() |
M. J. Gonzalez-Garcia, A. Gonzalez-Saiz, Beatriz de la Fuente, A. Morilla-Grasa, A. Mayo-Iscar, J. San-Jose, J. Feijo, M. E. Stern, and M. Calonge Exposure to a Controlled Adverse Environment Impairs the Ocular Surface of Subjects with Minimally Symptomatic Dry Eye Invest. Ophthalmol. Vis. Sci., September 1, 2007; 48(9): 4026 - 4032. [Abstract] [Full Text] [PDF] |
||||
![]() |
C. S. De Paiva, A. L. Villarreal, R. M. Corrales, H. T. Rahman, V. Y. Chang, W. J. Farley, M. E. Stern, J. Y. Niederkorn, D.-Q. Li, and S. C. Pflugfelder Dry Eye-Induced Conjunctival Epithelial Squamous Metaplasia Is Modulated by Interferon-{gamma} Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2553 - 2560. [Abstract] [Full Text] [PDF] |
||||
![]() |
K.-C. Yoon, C. S. De Paiva, H. Qi, Z. Chen, W. J. Farley, D.-Q. Li, and S. C. Pflugfelder Expression of Th-1 Chemokines and Chemokine Receptors on the Ocular Surface of C57BL/6 Mice: Effects of Desiccating Stress Invest. Ophthalmol. Vis. Sci., June 1, 2007; 48(6): 2561 - 2569. [Abstract] [Full Text] [PDF] |
||||
![]() |
R. M. Corrales, M. E. Stern, C. S. De Paiva, J. Welch, D.-Q. Li, and S. C. Pflugfelder Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest. Ophthalmol. Vis. Sci., August 1, 2006; 47(8): 3293 - 3302. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |