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CUTTING EDGE |
* Department of Biology, University of Rome Tor Vergata, Rome, Italy; and
Institute for Infectious Diseases and Molecular Medicine, and Division of Immunology, Health Science Faculty, University of Cape Town, South Africa
CD4+CD25+ T regulatory (Treg) cells are a CD4+ T cell subset involved in the control of the immune response. In vitro, murine CD4+CD25+ Treg cells inhibit CD4+CD25– Th cell proliferation induced by anti-CD3 mAb in the presence of APCs. The addition of IL-4 to cocultured cells inhibits CD4+CD25+ Treg cell-mediated suppression. Since all cell types used in the coculture express the IL-4R
chain, we used different combinations of CD4+CD25– Th cells, CD4+CD25+ Treg cells, and APCs from wild-type IL-4R+/+ or knockout IL-4R–/– mice. Results show that the engagement of the IL-4R chain on CD4+CD25– Th cells renders these cells resistant to suppression. Moreover, the addition of IL-4 promotes proliferation of IL-4R+/+CD4+CD25+ Treg cells, which preserve full suppressive competence. These findings support an essential role of IL-4 signaling for CD4+CD25– Th cell activation and indicate that IL-4-induced proliferation of CD4+CD25+ Treg cells is compatible with their suppressive activity.
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