| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
CUTTING EDGE |
* Department of Biology, University of Rome Tor Vergata, Rome, Italy; and
Institute for Infectious Diseases and Molecular Medicine, and Division of Immunology, Health Science Faculty, University of Cape Town, South Africa
CD4+CD25+ T regulatory (Treg) cells are a CD4+ T cell subset involved in the control of the immune response. In vitro, murine CD4+CD25+ Treg cells inhibit CD4+CD25– Th cell proliferation induced by anti-CD3 mAb in the presence of APCs. The addition of IL-4 to cocultured cells inhibits CD4+CD25+ Treg cell-mediated suppression. Since all cell types used in the coculture express the IL-4R
chain, we used different combinations of CD4+CD25– Th cells, CD4+CD25+ Treg cells, and APCs from wild-type IL-4R+/+ or knockout IL-4R–/– mice. Results show that the engagement of the IL-4R chain on CD4+CD25– Th cells renders these cells resistant to suppression. Moreover, the addition of IL-4 promotes proliferation of IL-4R+/+CD4+CD25+ Treg cells, which preserve full suppressive competence. These findings support an essential role of IL-4 signaling for CD4+CD25– Th cell activation and indicate that IL-4-induced proliferation of CD4+CD25+ Treg cells is compatible with their suppressive activity.
This article has been cited by other articles:
|
|
 |
|
  B. B. L. Pillemer, Z. Qi, B. Melgert, T. B. Oriss, P. Ray, and A. Ray STAT6 Activation Confers upon T Helper Cells Resistance to Suppression by Regulatory T Cells J. Immunol., July 1, 2009; 183(1): 155 - 163. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Nazarov-Stoica, J. Surls, C. Bona, S. Casares, and T.-D. Brumeanu CD28 Signaling in T Regulatory Precursors Requires p56lck and Rafts Integrity to Stabilize the Foxp3 Message J. Immunol., January 1, 2009; 182(1): 102 - 110. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. M. Dittrich, H.-C. Chen, L. Xu, P. Ranney, S. Connolly, T. O. Yarovinsky, and H. K. Bottomly A New Mechanism for Inhalational Priming: IL-4 Bypasses Innate Immune Signals J. Immunol., November 15, 2008; 181(10): 7307 - 7315. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Wang, N. van Panhuys, J. Hu-Li, S. Kim, G. Le Gros, and B. Min Blimp-1 Induced by IL-4 Plays a Critical Role in Suppressing IL-2 Production in Activated CD4 T Cells J. Immunol., October 15, 2008; 181(8): 5249 - 5256. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Hao, J. Yuan, S. Xu, M. A. Munegowda, Y. Deng, J. Gordon, Z. Xing, and J. Xiang Antigen Specificity Acquisition of Adoptive CD4+ Regulatory T Cells via Acquired Peptide-MHC Class I Complexes J. Immunol., August 15, 2008; 181(4): 2428 - 2437. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. S. Lee, W. Gao, S. Mazzola, M. N. Thomas, E. Csizmadia, L. E Otterbein, F. H. Bach, and H. Wang Heme oxygenase-1, carbon monoxide, and bilirubin induce tolerance in recipients toward islet allografts by modulating T regulatory cells FASEB J, November 1, 2007; 21(13): 3450 - 3457. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. L. Christy and M. A. Brown The Multitasking Mast Cell: Positive and Negative Roles in the Progression of Autoimmunity J. Immunol., September 1, 2007; 179(5): 2673 - 2679. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Wang, M.-C. Huang, and E. J. Goetzl Type 1 Sphingosine 1-Phosphate G Protein-Coupled Receptor (S1P1) Mediation of Enhanced IL-4 Generation by CD4 T Cells from S1P1 Transgenic Mice J. Immunol., April 15, 2007; 178(8): 4885 - 4890. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 N. K. Crellin, R. V. Garcia, and M. K. Levings Altered activation of AKT is required for the suppressive function of human CD4+CD25+ T regulatory cells Blood, March 1, 2007; 109(5): 2014 - 2022. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Hubeau, I. Apostolou, and L. Kobzik Targeting of CD25 and Glucocorticoid-Induced TNF Receptor Family-Related Gene-Expressing T Cells Differentially Modulates Asthma Risk in Offspring of Asthmatic and Normal Mother Mice J. Immunol., February 1, 2007; 178(3): 1477 - 1487. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Balic, Y. M. Harcus, M. D. Taylor, F. Brombacher, and R. M. Maizels IL-4R signaling is required to induce IL-10 for the establishment of Th2 dominance Int. Immunol., October 1, 2006; 18(10): 1421 - 1431. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Grimbert, S. Bouguermouh, N. Baba, T. Nakajima, Z. Allakhverdi, D. Braun, H. Saito, M. Rubio, G. Delespesse, and M. Sarfati Thrombospondin/CD47 Interaction: A Pathway to Generate Regulatory T Cells from Human CD4+CD25- T Cells in Response to Inflammation J. Immunol., September 15, 2006; 177(6): 3534 - 3541. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
