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BRIEF REVIEWS |
* Department of Experimental and Diagnostic Medicine, Section of General Pathology, and
Interdisciplinary Center for the Study of Inflammation, University of Ferrara, Ferrara, Italy;
Institute of Haematology and Medical Oncology "L. & A. Seragnoli," University of Bologna, Bologna, Italy; and
Department of Pneumology, University of Freiburg, Freiburg, Germany.
Human IL-1 family proteins are key mediators of the host response to infections, injury, and immunologic challenges. The mechanism by which IL-1 activates proinflammatory responses in target cells, and the plasma membrane receptors involved, is fairly well known. This has led to the development of innovative drugs that block IL-1 downstream to its synthesis and secretion. On the contrary, the mechanism of IL-1 and other IL-1 family members (e.g., IL-18) maturation and release is incompletely understood. Accruing evidence points to a plasma membrane receptor for extracellular ATP, the P2X7 receptor, as a key player in both processes. A deeper understanding of the mechanism by which the P2X7 receptor triggers IL-1 maturation and exteriorization may suggest novel avenues for the treatment of inflammatory diseases and provide a deeper insight in the fundamental mechanism of protease activation and cellular export of proteins lacking a leader sequence.
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G. R. Dubyak Go It Alone No More P2X7 Joins the Society of Heteromeric ATP-Gated Receptor Channels Mol. Pharmacol., December 1, 2007; 72(6): 1402 - 1405. [Abstract] [Full Text] [PDF]
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L. Stokes and A. Surprenant Purinergic P2Y2 Receptors Induce Increased MCP-1/CCL2 Synthesis and Release from Rat Alveolar and Peritoneal Macrophages J. Immunol., November 1, 2007; 179(9): 6016 - 6023. [Abstract] [Full Text] [PDF]
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S. Hong, A. Brass, M. Seman, F. Haag, F. Koch-Nolte, and G. R. Dubyak Lipopolysaccharide, IFN-{gamma}, and IFN-beta Induce Expression of the Thiol-Sensitive ART2.1 Ecto-ADP-Ribosyltransferase in Murine Macrophages J. Immunol., November 1, 2007; 179(9): 6215 - 6227. [Abstract] [Full Text] [PDF]
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N. Bles, M. Horckmans, A. Lefort, F. Libert, P. Macours, H. El Housni, F. Marteau, J.-M. Boeynaems, and D. Communi Gene Expression Profiling Defines ATP as a Key Regulator of Human Dendritic Cell Functions J. Immunol., September 15, 2007; 179(6): 3550 - 3558. [Abstract] [Full Text] [PDF]
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T. Darville, L. Welter-Stahl, C. Cruz, A. A. Sater, C. W. Andrews Jr., and D. M. Ojcius Effect of the Purinergic Receptor P2X7 on Chlamydia Infection in Cervical Epithelial Cells and Vaginally Infected Mice J. Immunol., September 15, 2007; 179(6): 3707 - 3714. [Abstract] [Full Text] [PDF]
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M. W. Buczynski, D. L. Stephens, R. C. Bowers-Gentry, A. Grkovich, R. A. Deems, and E. A. Dennis TLR-4 and Sustained Calcium Agonists Synergistically Produce Eicosanoids Independent of Protein Synthesis in RAW264.7 Cells J. Biol. Chem., August 3, 2007; 282(31): 22834 - 22847. [Abstract] [Full Text] [PDF]
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F. S. Sutterwala, Y. Ogura, and R. A. Flavell The inflammasome in pathogen recognition and inflammation J. Leukoc. Biol., August 1, 2007; 82(2): 259 - 264. [Abstract] [Full Text] [PDF]
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L. Franchi, T.-D. Kanneganti, G. R. Dubyak, and G. Nunez Differential Requirement of P2X7 Receptor and Intracellular K+ for Caspase-1 Activation Induced by Intracellular and Extracellular Bacteria J. Biol. Chem., June 29, 2007; 282(26): 18810 - 18818. [Abstract] [Full Text] [PDF]
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M. Baroni, C. Pizzirani, M. Pinotti, D. Ferrari, E. Adinolfi, S. Calzavarini, P. Caruso, F. Bernardi, and F. Di Virgilio Stimulation of P2 (P2X7) receptors in human dendritic cells induces the release of tissue factor-bearing microparticles FASEB J, June 1, 2007; 21(8): 1926 - 1933. [Abstract] [Full Text] [PDF]
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 K.-H. Lee, S. S. Park, I. Kim, J. H. Kim, E. K. Ra, S.-S. Yoon, Y.-C. Hong, S. Park, and B. K. Kim P2X7 receptor polymorphism and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation Haematologica, May 1, 2007; 92(5): 651 - 657. [Abstract] [Full Text] [PDF]
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C. Pizzirani, D. Ferrari, P. Chiozzi, E. Adinolfi, D. Sandona, E. Savaglio, and F. Di Virgilio Stimulation of P2 receptors causes release of IL-1{beta}-loaded microvesicles from human dendritic cells Blood, May 1, 2007; 109(9): 3856 - 3864. [Abstract] [Full Text] [PDF]
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 G. Burnstock Physiology and Pathophysiology of Purinergic Neurotransmission Physiol Rev, April 1, 2007; 87(2): 659 - 797. [Abstract] [Full Text] [PDF]
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C. M. Cruz, A. Rinna, H. J. Forman, A. L. M. Ventura, P. M. Persechini, and D. M. Ojcius ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages J. Biol. Chem., February 2, 2007; 282(5): 2871 - 2879. [Abstract] [Full Text] [PDF]
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P. Pelegrin and A. Surprenant Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1beta Release through a Dye Uptake-independent Pathway J. Biol. Chem., January 26, 2007; 282(4): 2386 - 2394. [Abstract] [Full Text] [PDF]
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M. T. Young, P. Pelegrin, and A. Surprenant Amino Acid Residues in the P2X7 Receptor that Mediate Differential Sensitivity to ATP and BzATP Mol. Pharmacol., January 1, 2007; 71(1): 92 - 100. [Abstract] [Full Text] [PDF]
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 A. Simon and J. W. M. van der Meer Pathogenesis of familial periodic fever syndromes or hereditary autoinflammatory syndromes Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R86 - R98. [Abstract] [Full Text] [PDF]
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C. Stock, T. Schilling, A. Schwab, and C. Eder Lysophosphatidylcholine Stimulates IL-1beta Release from Microglia via a P2X7 Receptor-Independent Mechanism J. Immunol., December 15, 2006; 177(12): 8560 - 8568. [Abstract] [Full Text] [PDF]
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P. Honore, D. Donnelly-Roberts, M. T. Namovic, G. Hsieh, C. Z. Zhu, J. P. Mikusa, G. Hernandez, C. Zhong, D. M. Gauvin, P. Chandran, et al. A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat J. Pharmacol. Exp. Ther., December 1, 2006; 319(3): 1376 - 1385. [Abstract] [Full Text] [PDF]
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R. S. Kornbluth and G. W. Stone Immunostimulatory combinations: designing the next generation of vaccine adjuvants J. Leukoc. Biol., November 1, 2006; 80(5): 1084 - 1102. [Abstract] [Full Text] [PDF]
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 F. S. Sutterwala, Y. Ogura, D. S. Zamboni, C. R. Roy, and R. A. Flavell NALP3: a key player in caspase-1 activation Innate Immunity, August 1, 2006; 12(4): 251 - 256. [Abstract] [PDF]
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