The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Related articles in The JI
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jouvin-Marche, E.
Right arrow Articles by Marche, P. N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jouvin-Marche, E.
Right arrow Articles by Marche, P. N.
The Journal of Immunology, 2006, 176: 3490-3497.
Copyright © 2006 by The American Association of Immunologists

Overexpression of Cellular Prion Protein Induces an Antioxidant Environment Altering T Cell Development in the Thymus1

Evelyne Jouvin-Marche2,*, Valérie Attuil-Audenis2,*, Catherine Aude-Garcia2,*, Walid Rachidi3,{dagger}, Mark Zabel§, Valérie Podevin-Dimster{ddagger}, Carole Siret||, Christoph Huber§, Marianne Martinic, Jacqueline Riondel{dagger}, Christian L. Villiers*, Alain Favier{dagger}, Philippe Naquet||, Jean-Yves Cesbron{ddagger} and Patrice N. Marche4,*

* Laboratoire d’Immunochimie, Commissariat à l’Energie Atomique, Institut National de la Santé et de la Recherche Médicale Unité 548, Université J. Fourier, Grenoble, France; {dagger} Laboratoire de Biologie du Stress Oxydant and {ddagger} Transmission et Pathogénèse des Maladies à Prions, Centre National de la Recherche Scientifique FRE 2685, Université J. Fourier, La Tronche, France; § Neuropathology Institute, University Hospital of Zurich and Institute of Experimental Immunology, Zurich, Switzerland; and || CIML, Centre National de la Recherche Scientifique-Institut National de la Santé et de la Recherche Médicale-Université de la Méditerranée, Parc scientifique de Luminy, Marseille, France

Cellular prion protein (PrPC) is an ubiquitously expressed glycoprotein whose roles are still widely discussed, particularly in the field of immunology. Using TgA20- and Tg33-transgenic mice overexpressing PrPC, we investigated the consequences of this overexpression on T cell development. In both models, overexpression of PrPC induces strong alterations at different steps of T cell maturation. On TgA20 mice, we observed that these alterations are cell autonomous and lead to a decrease of {alpha}beta T cells and a concomitant increase of {gamma}{delta} T cell numbers. PrPC has been shown to bind and chelate copper and, interestingly, under a copper supplementation diet, TgA20 mice presented a partial restoration of the {alpha}beta T cell development, suggesting that PrPC overexpression, by chelating copper, generates an antioxidant context differentially impacting on {alpha}beta and {gamma}{delta} T cell lineage.


Related articles in The JI:

IN THIS ISSUE

The JI 2006 176: 3289-3290. [Full Text]  





HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.