HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Ercolini, A. M. Articles by Miller, S. D. Search for Related Content PubMed PubMed Citation Articles by Ercolini, A. M. Articles by Miller, S. D.

Mechanisms of Immunopathology in Murine Models of Central Nervous System Demyelinating Disease¹

Department of Microbiology-Immunology and Interdepartmental Immunobiology Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611

Many disorders of the CNS, such as multiple sclerosis (MS), are characterized by the loss of the myelin sheath surrounding nerve axons. MS is associated with infiltration of inflammatory cells into the brain and spinal cord, which may be the primary cause of demyelination or which may be induced secondary to axonal damage. Both the innate and adaptive arms of the immune system have been reported to play important roles in myelin destruction. Numerous murine demyelinating models, both virus-induced and/or autoimmune, are available, which reflect the clinical and pathological variability seen in human disease. This review will discuss the immunopathologic mechanisms involved in these demyelinating disease models.

This article has been cited by other articles:

				A. M. Ercolini and S. D. Miller Molecular Mimics Can Induce Novel Self Peptide-Reactive CD4+ T Cell Clonotypes in Autoimmune Disease J. Immunol., November 15, 2007; 179(10): 6604 - 6612. [Abstract] [Full Text] [PDF]

				E. K. Mathey, T. Derfuss, M. K. Storch, K. R. Williams, K. Hales, D. R. Woolley, A. Al-Hayani, S. N. Davies, M. N. Rasband, T. Olsson, et al. Neurofascin as a novel target for autoantibody-mediated axonal injury J. Exp. Med., October 1, 2007; 204(10): 2363 - 2372. [Abstract] [Full Text] [PDF]

				J. M. Reynolds, Q. Liu, K. C. Brittingham, Y. Liu, M. Gruenthal, C. Z. Gorgun, G. S. Hotamisligil, R. D. Stout, and J. Suttles Deficiency of Fatty Acid-Binding Proteins in Mice Confers Protection from Development of Experimental Autoimmune Encephalomyelitis J. Immunol., July 1, 2007; 179(1): 313 - 321. [Abstract] [Full Text] [PDF]

				R. Balabanov, K. Strand, R. Goswami, E. McMahon, W. Begolka, S. D. Miller, and B. Popko Interferon-{gamma}-Oligodendrocyte Interactions in the Regulation of Experimental Autoimmune Encephalomyelitis J. Neurosci., February 21, 2007; 27(8): 2013 - 2024. [Abstract] [Full Text] [PDF]