The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Whitmire, J. K.
Right arrow Articles by Whitton, J. L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitmire, J. K.
Right arrow Articles by Whitton, J. L.
The Journal of Immunology, 2006, 176: 3028-3036.
Copyright © 2006 by The American Association of Immunologists

Precursor Frequency, Nonlinear Proliferation, and Functional Maturation of Virus-Specific CD4+ T Cells1

Jason K. Whitmire, Nicola Benning and J. Lindsay Whitton2

Department of Neuropharmacology, The Scripps Research Institute, La Jolla, CA 92037

The early events regulating antiviral CD4 responses were tracked using an adoptive transfer model. CD4+ T cell expansion was nonlinear, with a lengthy lag phase followed by 2 days of explosive proliferation. A small number of naive Ag-specific CD4+ T cells were found in nonlymphoid tissues and, in the 8 days following infection, the number of activated cells increased in all tissues analyzed, and their effector functions matured. Finally, we show that a naive mouse contains ~100 naive CD4+ precursor cells specific for a single epitope, a precursor frequency of ~10–5, similar to that of naive CD8+ T cells, indicating that the ~50-fold difference in size of the two responses to virus infection is determined by something other than the number of precursor cells.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
J. K. Whitmire, N. Benning, B. Eam, and J. L. Whitton
Increasing the CD4+ T Cell Precursor Frequency Leads to Competition for IFN-{gamma} Thereby Degrading Memory Cell Quantity and Quality
J. Immunol., May 15, 2008; 180(10): 6777 - 6785.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. K. Whitmire, B. Eam, N. Benning, and J. L. Whitton
Direct Interferon-{gamma} Signaling Dramatically Enhances CD4+ and CD8+ T Cell Memory
J. Immunol., July 15, 2007; 179(2): 1190 - 1197.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
M. L. Ford, B. H. Koehn, M. E. Wagener, W. Jiang, S. Gangappa, T. C. Pearson, and C. P. Larsen
Antigen-specific precursor frequency impacts T cell proliferation, differentiation, and requirement for costimulation
J. Exp. Med., February 19, 2007; 204(2): 299 - 309.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. E. Munroe and G. A. Bishop
A Costimulatory Function for T Cell CD40
J. Immunol., January 15, 2007; 178(2): 671 - 682.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kedzierska, E. B. Day, J. Pi, S. B. Heard, P. C. Doherty, S. J. Turner, and S. Perlman
Quantification of Repertoire Diversity of Influenza-Specific Epitopes with Predominant Public or Private TCR Usage
J. Immunol., November 15, 2006; 177(10): 6705 - 6712.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.