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Human NK Cells Positively Regulate T Cells in Response to Mycobacterium tuberculosis¹

Ruijun Zhang^2,*,, Xiaodong Zheng^2,*, Baiqing Li^*, Haiming Wei^* and Zhigang Tian^3,*,

^* Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China; and Institute of Immunopharmacology and Immunotherapy, School of Pharmaceutical Sciences, Shandong University, Jinan, China

The decrease in NK cell activity and the loss of T cells in active pulmonary tuberculosis patients have been reported. In this study, we observed that the proliferating response of T cells to the heat-treated Ags of Mycobacterium tuberculosis from different individuals was noted to be dependent on the content or function of NK cells in PBMC in a population study. We also found that NK cells were directly rapidly activated by the heat-treated Ags from M. tuberculosis (H37Ra) in vitro; in turn, the activated NK cells improved T cell proliferation both by CD54-mediated cell-cell contact through the forming immune synapse and by soluble factors TNF-, GM-CSF, and IL-12, but not IFN-. Our results demonstrated that an interaction between NK cells and T cells existed in antituberculosis immunity. Up-regulating the function of NK cells might be beneficial to the prevention and control of pulmonary tuberculosis.

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The JI 2006 176: 2051-2052. [Full Text]  

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