| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Department of Immunology, The Weizmann Institute of Science, Rehovot, Israel; and
Formation de Recherche en Evolution 2736, Centre National de la Recherche Scientifique, BioMérieux, Institut Fédératif de Recherche 128 Biosciences Lyon Gerland, Lyon, France
The lamina propria that underlies and stabilizes the gut lining epithelium is densely populated with strategically located mononuclear phagocytes. Collectively, these lamina propria macrophages and dendritic cells (DC) are believed to be crucial for tissue homeostasis as well as the innate and adaptive host defense. Lamina propria DC were recently shown to gain direct access to the intestinal lumen by virtue of epithelium-penetrating dendrites. However, the role of these structures in pathogen uptake remains under debate. In this study, we report that entry of a noninvasive model pathogen (Aspergillus fumigatus conidia) into the murine small intestinal lamina propria persists in the absence of either transepithelial dendrites or lamina propria DC and macrophages. Our results suggest the existence of multiple pathogen entry pathways and point at the importance of villus M cells in the uptake of gut lumen Ags. Interestingly, transepithelial dendrites seem altogether absent from the small intestine of BALB/c mice suggesting that the function of lamina propria DC extensions resides in their potential selectivity for luminal Ags, rather than in general uptake or gut homeostasis.
Related articles in The JI:
This article has been cited by other articles:
|
|
 |
|
  T. Ueno, K. Tanaka, M. Jurewicz, T. Murayama, I. Guleria, P. Fiorina, J. C. Paez, A. Augello, A. Vergani, M. Wong, et al. Divergent Role of Donor Dendritic Cells in Rejection versus Tolerance of Allografts J. Am. Soc. Nephrol., March 1, 2009; 20(3): 535 - 544. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A M Westendorf, D Fleissner, L Groebe, S Jung, A D Gruber, W Hansen, and J Buer CD4+Foxp3+ regulatory T cell expansion induced by antigen-driven interaction with intestinal epithelial cells independent of local dendritic cells Gut, February 1, 2009; 58(2): 211 - 219. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. A. Hume Macrophages as APC and the Dendritic Cell Myth J. Immunol., November 1, 2008; 181(9): 5829 - 5835. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Vallon-Eberhard, A. Makovitzki, A. Beauvais, J.-P. Latge, S. Jung, and Y. Shai Efficient Clearance of Aspergillus fumigatus in Murine Lungs by an Ultrashort Antimicrobial Lipopeptide, Palmitoyl-Lys-Ala-DAla-Lys Antimicrob. Agents Chemother., September 1, 2008; 52(9): 3118 - 3126. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Hapfelmeier, A. J. Muller, B. Stecher, P. Kaiser, M. Barthel, K. Endt, M. Eberhard, R. Robbiani, C. A. Jacobi, M. Heikenwalder, et al. Microbe sampling by mucosal dendritic cells is a discrete, MyD88-independent stepin {Delta}invG S. Typhimurium colitis J. Exp. Med., February 18, 2008; 205(2): 437 - 450. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Abe, K. P. Nguyen, S. D. Fine, J.-H. Mo, C. Shen, S. Shenouda, M. Corr, S. Jung, J. Lee, L. Eckmann, et al. Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells PNAS, October 23, 2007; 104(43): 17022 - 17027. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Pabst, G. Bernhardt, and R. Forster The impact of cell-bound antigen transport on mucosal tolerance induction J. Leukoc. Biol., October 1, 2007; 82(4): 795 - 800. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Sapoznikov, J. A.A. Fischer, T. Zaft, R. Krauthgamer, A. Dzionek, and S. Jung Organ-dependent in vivo priming of naive CD4+,but not CD8+,T cells by plasmacytoid dendritic cells J. Exp. Med., August 6, 2007; 204(8): 1923 - 1933. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Cleret, A. Quesnel-Hellmann, A. Vallon-Eberhard, B. Verrier, S. Jung, D. Vidal, J. Mathieu, and J.-N. Tournier Lung Dendritic Cells Rapidly Mediate Anthrax Spore Entry through the Pulmonary Route J. Immunol., June 15, 2007; 178(12): 7994 - 8001. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Halle, D. Bumann, H. Herbrand, Y. Willer, S. Dahne, R. Forster, and O. Pabst Solitary Intestinal Lymphoid Tissue Provides a Productive Port of Entry for Salmonella enterica Serovar Typhimurium Infect. Immun., April 1, 2007; 75(4): 1577 - 1585. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Landsman, C. Varol, and S. Jung Distinct Differentiation Potential of Blood Monocyte Subsets in the Lung J. Immunol., February 15, 2007; 178(4): 2000 - 2007. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Varol, L. Landsman, D. K. Fogg, L. Greenshtein, B. Gildor, R. Margalit, V. Kalchenko, F. Geissmann, and S. Jung Monocytes give rise to mucosal, but not splenic, conventional dendritic cells J. Exp. Med., January 22, 2007; 204(1): 171 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Chieppa, M. Rescigno, A. Y.C. Huang, and R. N. Germain Dynamic imaging of dendritic cell extension into the small bowel lumen in response to epithelial cell TLR engagement J. Exp. Med., December 25, 2006; 203(13): 2841 - 2852. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. D. Barnes, M. A. Bergman, J. Mecsas, and R. R. Isberg Yersinia pseudotuberculosis disseminates directly from a replicating bacterial pool in the intestine J. Exp. Med., June 12, 2006; 203(6): 1591 - 1601. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
