|
|
||||||||


* Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305;
Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan; and
Department of Immunology, DNAX Research, Palo Alto, CA 94304
We recently reported that mast cells stimulated via Fc
RI aggregation can enhance T cell activation by a TNF-dependent mechanism. However, the molecular mechanisms responsible for such IgE-, Ag- (Ag-), and mast cell-dependent enhancement of T cell activation remain unknown. In this study we showed that mouse bone marrow-derived cultured mast cells express various costimulatory molecules, including members of the B7 family (ICOS ligand (ICOSL), PD-L1, and PD-L2) and the TNF/TNFR families (OX40 ligand (OX40L), CD153, Fas, 4-1BB, and glucocorticoid-induced TNFR). ICOSL, PD-L1, PD-L2, and OX40L also are expressed on APCs such as dendritic cells and can modulate T cell function. We found that IgE- and Ag-dependent mast cell enhancement of T cell activation required secreted TNF; that TNF can increase the surface expression of OX40, ICOS, PD-1, and other costimulatory molecules on CD3+ T cells; and that a neutralizing Ab to OX40L, but not neutralizing Abs to ICOSL or PD-L1, significantly reduced IgE/Ag-dependent mast cell-mediated enhancement of T cell activation. These results indicate that the secretion of soluble TNF and direct cell-cell interactions between mast cell OX40L and T cell OX40 contribute to the ability of IgE- and Ag-stimulated mouse mast cells to enhance T cell activation.
This article has been cited by other articles:
![]() |
M. Sobiesiak, E. Shumilina, R. S. Lam, F. Wolbing, N. Matzner, S. Kaesler, I. M. Zemtsova, A. Lupescu, N. Zahir, D. Kuhl, et al. Impaired Mast Cell Activation in Gene-Targeted Mice Lacking the Serum- and Glucocorticoid-Inducible Kinase SGK1 J. Immunol., October 1, 2009; 183(7): 4395 - 4402. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Piconese, G. Gri, C. Tripodo, S. Musio, A. Gorzanelli, B. Frossi, R. Pedotti, C. E. Pucillo, and M. P. Colombo Mast cells counteract regulatory T-cell suppression through interleukin-6 and OX40/OX40L axis toward Th17-cell differentiation Blood, September 24, 2009; 114(13): 2639 - 2648. [Abstract] [Full Text] [PDF] |
||||
![]() |
M. X. Ierna, H. E. Scales, C. Mueller, and C. E. Lawrence Transmembrane Tumor Necrosis Factor Alpha Is Required for Enteropathy and Is Sufficient To Promote Parasite Expulsion in Gastrointestinal Helminth Infection Infect. Immun., September 1, 2009; 77(9): 3879 - 3885. [Abstract] [Full Text] [PDF] |
||||
![]() |
N. A. Forward, S. J. Furlong, Y. Yang, T.-J. Lin, and D. W. Hoskin Mast Cells Down-Regulate CD4+CD25+ T Regulatory Cell Suppressor Function via Histamine H1 Receptor Interaction J. Immunol., September 1, 2009; 183(5): 3014 - 3022. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Ellem, H. Wang, M. Poutanen, and G. P. Risbridger Increased Endogenous Estrogen Synthesis Leads to the Sequential Induction of Prostatic Inflammation (Prostatitis) and Prostatic Pre-Malignancy Am. J. Pathol., September 1, 2009; 175(3): 1187 - 1199. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Xiong, J. MacTaggart, R. Knispel, J. Worth, Y. Persidsky, and B. T. Baxter Blocking TNF-{alpha} Attenuates Aneurysm Formation in a Murine Model J. Immunol., August 15, 2009; 183(4): 2741 - 2746. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Gounaris, N. R. Blatner, K. Dennis, F. Magnusson, M. F. Gurish, T. B. Strom, P. Beckhove, F. Gounari, and K. Khazaie T-Regulatory Cells Shift from a Protective Anti-Inflammatory to a Cancer-Promoting Proinflammatory Phenotype in Polyposis Cancer Res., July 1, 2009; 69(13): 5490 - 5497. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kambayashi, E. J. Allenspach, J. T. Chang, T. Zou, J. E. Shoag, S. L. Reiner, A. J. Caton, and G. A. Koretzky Inducible MHC Class II Expression by Mast Cells Supports Effector and Regulatory T Cell Activation J. Immunol., April 15, 2009; 182(8): 4686 - 4695. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. H. Rork, K. L. Wallace, D. P. Kennedy, M. A. Marshall, A. R. Lankford, and J. Linden Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation Am J Physiol Heart Circ Physiol, November 1, 2008; 295(5): H1825 - H1833. [Abstract] [Full Text] [PDF] |
||||
![]() |
B. A. Zabel, S. Nakae, L. Zuniga, J.-Y. Kim, T. Ohyama, C. Alt, J. Pan, H. Suto, D. Soler, S. J. Allen, et al. Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis J. Exp. Med., September 29, 2008; 205(10): 2207 - 2220. [Abstract] [Full Text] [PDF] |
||||
![]() |
J. O. Jurado, I. B. Alvarez, V. Pasquinelli, G. J. Martinez, M. F. Quiroga, E. Abbate, R. M. Musella, H. E. Chuluyan, and V. E. Garcia Programmed Death (PD)-1:PD-Ligand 1/PD-Ligand 2 Pathway Inhibits T Cell Effector Functions during Human Tuberculosis J. Immunol., July 1, 2008; 181(1): 116 - 125. [Abstract] [Full Text] [PDF] |
||||
![]() |
E. Shumilina, R. S. Lam, F. Wolbing, N. Matzner, I. M. Zemtsova, M. Sobiesiak, H. Mahmud, U. Sausbier, T. Biedermann, P. Ruth, et al. Blunted IgE-Mediated Activation of Mast Cells in Mice Lacking the Ca2+-Activated K+ Channel KCa3.1 J. Immunol., June 15, 2008; 180(12): 8040 - 8047. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Reuter, A. Heinz, M. Sieren, R. Wiewrodt, E. W. Gelfand, M. Stassen, R. Buhl, and C. Taube Mast cell-derived tumour necrosis factor is essential for allergic airway disease Eur. Respir. J., April 1, 2008; 31(4): 773 - 782. [Abstract] [Full Text] [PDF] |
||||
![]() |
T. Kambayashi, J. D. Baranski, R. G. Baker, T. Zou, E. J. Allenspach, J. E. Shoag, P. L. Jones, and G. A. Koretzky Indirect involvement of allergen-captured mast cells in antigen presentation Blood, February 1, 2008; 111(3): 1489 - 1496. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nakae, M. Iikura, H. Suto, H. Akiba, D. T. Umetsu, R. H. DeKruyff, H. Saito, and S. J. Galli TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells Blood, October 1, 2007; 110(7): 2565 - 2568. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. J. Jenkins, G. Perona-Wright, A. G. F. Worsley, N. Ishii, and A. S. MacDonald Dendritic Cell Expression of OX40 Ligand Acts as a Costimulatory, Not Polarizing, Signal for Optimal Th2 Priming and Memory Induction In Vivo J. Immunol., September 15, 2007; 179(6): 3515 - 3523. [Abstract] [Full Text] [PDF] |
||||
![]() |
A. L. Christy and M. A. Brown The Multitasking Mast Cell: Positive and Negative Roles in the Progression of Autoimmunity J. Immunol., September 1, 2007; 179(5): 2673 - 2679. [Abstract] [Full Text] [PDF] |
||||
![]() |
V. Heib, M. Becker, T. Warger, G. Rechtsteiner, C. Tertilt, M. Klein, T. Bopp, C. Taube, H. Schild, E. Schmitt, et al. Mast cells are crucial for early inflammation, migration of Langerhans cells, and CTL responses following topical application of TLR7 ligand in mice Blood, August 1, 2007; 110(3): 946 - 953. [Abstract] [Full Text] [PDF] |
||||
![]() |
S. Nakae, Y. Iwakura, H. Suto, and S. J. Galli Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17 J. Leukoc. Biol., May 1, 2007; 81(5): 1258 - 1268. [Abstract] [Full Text] [PDF] |
||||
![]() |
W. Liu, D. P. Evanoff, X. Chen, and Y. Luo Urinary Bladder Epithelium Antigen Induces CD8+ T Cell Tolerance, Activation, and Autoimmune Response J. Immunol., January 1, 2007; 178(1): 539 - 546. [Abstract] [Full Text] [PDF] |
||||
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |