The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Harcourt, J.
Right arrow Articles by Tripp, R. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Harcourt, J.
Right arrow Articles by Tripp, R. A.
Right arrowPubmed/NCBI databases
*Gene
*Substance via MeSH
The Journal of Immunology, 2006, 176: 1600-1608.
Copyright © 2006 by The American Association of Immunologists

Respiratory Syncytial Virus G Protein and G Protein CX3C Motif Adversely Affect CX3CR1+ T Cell Responses

Jennifer Harcourt*, Rene Alvarez{dagger}, Les P. Jones{dagger}, Christine Henderson{dagger}, Larry J. Anderson* and Ralph A. Tripp1,{dagger}

* Division of Viral and Rickettsial Diseases, Viral and Enteric Virus Branch, Centers for Disease Control and Prevention, Atlanta, GA 30333; and {dagger} Center for Disease Intervention, Department of Infectious Diseases, University of Georgia, College of Veterinary Medicine, Athens, GA 30602

Interactions between fractalkine (CX3CL1) and its receptor, CX3CR1, mediate leukocyte adhesion, activation, and trafficking. The respiratory syncytial virus (RSV) G protein has a CX3C chemokine motif that can bind CX3CR1 and modify CXCL1-mediated responses. In this study, we show that expression of the RSV G protein or the G protein CX3C motif during infection is associated with reduced CX3CR1+ T cell trafficking to the lung, reduced frequencies of RSV-specific, MHC class I-restricted IFN-{gamma}-expressing cells, and lower numbers of IL-4- and CX3CL1-expressing cells. In addition, we show that CX3CR1+ cells constitute a major component of the cytotoxic response to RSV infection. These results suggest that G protein and the G protein CX3C motif reduce the antiviral T cell response to RSV infection.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
E. J. Collarini, F. E.-H. Lee, O. Foord, M. Park, G. Sperinde, H. Wu, W. D. Harriman, S. F. Carroll, S. L. Ellsworth, L. J. Anderson, et al.
Potent High-Affinity Antibodies for Treatment and Prophylaxis of Respiratory Syncytial Virus Derived from B Cells of Infected Patients
J. Immunol., November 15, 2009; 183(10): 6338 - 6345.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
Y. Liu, D. L. Haas, S. Poore, S. Isakovic, M. Gahan, S. Mahalingam, Z. F. Fu, and R. A. Tripp
Human Metapneumovirus Establishes Persistent Infection in the Lungs of Mice and Is Reactivated by Glucocorticoid Treatment
J. Virol., July 1, 2009; 83(13): 6837 - 6848.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. L. Moore, M. H. Chi, C. Luongo, N. W. Lukacs, V. V. Polosukhin, M. M. Huckabee, D. C. Newcomb, U. J. Buchholz, J. E. Crowe Jr., K. Goleniewska, et al.
A Chimeric A2 Strain of Respiratory Syncytial Virus (RSV) with the Fusion Protein of RSV Strain Line 19 Exhibits Enhanced Viral Load, Mucus, and Airway Dysfunction
J. Virol., May 1, 2009; 83(9): 4185 - 4194.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
C. Miao, G. U. Radu, H. Caidi, R. A. Tripp, L. J. Anderson, and L. M. Haynes
Treatment with respiratory syncytial virus G glycoprotein monoclonal antibody or F(ab')2 components mediates reduced pulmonary inflammation in mice
J. Gen. Virol., May 1, 2009; 90(5): 1119 - 1123.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
W. Zhang and R. A. Tripp
RNA Interference Inhibits Respiratory Syncytial Virus Replication and Disease Pathogenesis without Inhibiting Priming of the Memory Immune Response
J. Virol., December 15, 2008; 82(24): 12221 - 12231.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Bukreyev, L. Yang, J. Fricke, L. Cheng, J. M. Ward, B. R. Murphy, and P. L. Collins
The Secreted Form of Respiratory Syncytial Virus G Glycoprotein Helps the Virus Evade Antibody-Mediated Restriction of Replication by Acting as an Antigen Decoy and through Effects on Fc Receptor-Bearing Leukocytes
J. Virol., December 15, 2008; 82(24): 12191 - 12204.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
J. R. Pallandre, K. Krzewski, R. Bedel, B. Ryffel, A. Caignard, P. S. Rohrlich, X. Pivot, P. Tiberghien, L. Zitvogel, J. L. Strominger, et al.
Dendritic cell and natural killer cell cross-talk: a pivotal role of CX3CL1 in NK cytoskeleton organization and activation
Blood, December 1, 2008; 112(12): 4420 - 4424.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
S. Munir, C. Le Nouen, C. Luongo, U. J. Buchholz, P. L. Collins, and A. Bukreyev
Nonstructural Proteins 1 and 2 of Respiratory Syncytial Virus Suppress Maturation of Human Dendritic Cells
J. Virol., September 1, 2008; 82(17): 8780 - 8796.
[Abstract] [Full Text] [PDF]

Home page
 J. Gen. Virol.Home page
T. M. Ward, V. Traina-Dorge, K. A. Davis, and W. L. Gray
Recombinant simian varicella viruses expressing respiratory syncytial virus antigens are immunogenic
J. Gen. Virol., March 1, 2008; 89(3): 741 - 750.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
P. L. Collins and B. S. Graham
Viral and Host Factors in Human Respiratory Syncytial Virus Pathogenesis
J. Virol., March 1, 2008; 82(5): 2040 - 2055.
[Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.