The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hayakawa, Y.
Right arrow Articles by Smyth, M. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hayakawa, Y.
Right arrow Articles by Smyth, M. J.
The Journal of Immunology, 2006, 176: 1517-1524.
Copyright © 2006 by The American Association of Immunologists

CD27 Dissects Mature NK Cells into Two Subsets with Distinct Responsiveness and Migratory Capacity1

Yoshihiro Hayakawa2 and Mark J. Smyth

Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia

Lineage differentiation and the formation of heterogeneous mature subsets are crucial for immune cells to maintain a breadth of responsiveness to pathogens while controlling reactivity to self. In this study, we report that CD27 is a key marker of the NK cell lineage, dissecting the mature Mac-1high NK cell pool into two functionally distinct subsets. The CD27low NK cell subset possesses a higher threshold to stimulation and appears to be tightly regulated by the expression of NK cell inhibitory receptors. Comparatively, the CD27high NK cell subset displays a greater effector function, exhibits a distinct tissue distribution and responsiveness to chemokines, and interacts productively with dendritic cells. Importantly, we have verified that CD27high and CD27low subsets with distinct cell surface phenotypes also exist in human peripheral blood. These findings clearly reclassify mature NK cells into two distinct subsets and begin to discern their specific role in immune responses.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
R. G. Hoover, G. Gullickson, and J. Kornbluth
Impaired NK Cytolytic Activity and Enhanced Tumor Growth in NK Lytic-Associated Molecule-Deficient Mice
J. Immunol., December 1, 2009; 183(11): 6913 - 6921.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Yu, M. Wei, H. Mao, J. Zhang, T. Hughes, T. Mitsui, I.-k. Park, C. Hwang, S. Liu, G. Marcucci, et al.
CD94 Defines Phenotypically and Functionally Distinct Mouse NK Cell Subsets
J. Immunol., October 15, 2009; 183(8): 4968 - 4974.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
E. F. Castillo, S. W. Stonier, L. Frasca, and K. S. Schluns
Dendritic Cells Support the In Vivo Development and Maintenance of NK Cells via IL-15 Trans-Presentation
J. Immunol., October 15, 2009; 183(8): 4948 - 4956.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
J. McGill, J. W. Heusel, and K. L. Legge
Innate immune control and regulation of influenza virus infections
J. Leukoc. Biol., October 1, 2009; 86(4): 803 - 812.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
N. Himoudi, M. Yan, G. Bouma, D. Morgenstern, R. Wallace, B. Seddon, J. Buddle, A. Eddaoudi, S. J. Howe, N. Cooper, et al.
Migratory and Antigen Presentation Functions of IFN-Producing Killer Dendritic Cells
Cancer Res., August 15, 2009; 69(16): 6598 - 6606.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
T. V. Mallidi, L. E. Craig, S. R. Schloemann, and J. K. Riley
Murine Endometrial and Decidual NK1.1+ Natural Killer Cells Display a B220+CD11c+ Cell Surface Phenotype
Biol Reprod, August 1, 2009; 81(2): 310 - 318.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
S. Seth, A.-M. Georgoudaki, B. J. Chambers, Q. Qiu, E. Kremmer, M. K. Maier, N. Czeloth, I. Ravens, R. Foerster, and G. Bernhardt
Heterogeneous expression of the adhesion receptor CD226 on murine NK and T cells and its function in NK-mediated killing of immature dendritic cells
J. Leukoc. Biol., July 1, 2009; 86(1): 91 - 101.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Manocha, R. Svend, A. Laouar, G. Liao, A. Bhan, J. Borst, C. Terhorst, and N. Manjunath
Blocking CD27-CD70 Costimulatory Pathway Suppresses Experimental Colitis
J. Immunol., July 1, 2009; 183(1): 270 - 276.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. Chiossone, J. Chaix, N. Fuseri, C. Roth, E. Vivier, and T. Walzer
Maturation of mouse NK cells is a 4-stage developmental program
Blood, May 28, 2009; 113(22): 5488 - 5496.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
M. A. Cooper, J. M. Elliott, P. A. Keyel, L. Yang, J. A. Carrero, and W. M. Yokoyama
Cytokine-induced memory-like natural killer cells
PNAS, February 10, 2009; 106(6): 1915 - 1919.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. Yadi, S. Burke, Z. Madeja, M. Hemberger, A. Moffett, and F. Colucci
Unique Receptor Repertoire in Mouse Uterine NK cells
J. Immunol., November 1, 2008; 181(9): 6140 - 6147.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
M. Wendel, I. E. Galani, E. Suri-Payer, and A. Cerwenka
Natural Killer Cell Accumulation in Tumors Is Dependent on IFN-{gamma} and CXCR3 Ligands
Cancer Res., October 15, 2008; 68(20): 8437 - 8445.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. V. Watt, D. M. Andrews, K. Takeda, M. J. Smyth, and Y. Hayakawa
IFN-{gamma}-Dependent Recruitment of Mature CD27high NK Cells to Lymph Nodes Primed by Dendritic Cells
J. Immunol., October 15, 2008; 181(8): 5323 - 5330.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
H. Guo, A. Samarakoon, B. Vanhaesebroeck, and S. Malarkannan
The p110{delta} of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation
J. Exp. Med., September 29, 2008; 205(10): 2419 - 2435.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
H. J. Pegram, J. T. Jackson, M. J. Smyth, M. H. Kershaw, and P. K. Darcy
Adoptive Transfer of Gene-Modified Primary NK Cells Can Specifically Inhibit Tumor Progression In Vivo
J. Immunol., September 1, 2008; 181(5): 3449 - 3455.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
A. W. MacFarlane IV, T. Yamazaki, M. Fang, L. J. Sigal, T. Kurosaki, and K. S. Campbell
Enhanced NK-cell development and function in BCAP-deficient mice
Blood, July 1, 2008; 112(1): 131 - 140.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Strowig, F. Brilot, and C. Munz
Noncytotoxic Functions of NK Cells: Direct Pathogen Restriction and Assistance to Adaptive Immunity
J. Immunol., June 15, 2008; 180(12): 7785 - 7791.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
G. Mignot, E. Ullrich, M. Bonmort, C. Menard, L. Apetoh, J. Taieb, D. Bosisio, S. Sozzani, M. Ferrantini, J. Schmitz, et al.
The Critical Role of IL-15 in the Antitumor Effects Mediated by the Combination Therapy Imatinib and IL-2
J. Immunol., May 15, 2008; 180(10): 6477 - 6483.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
T. Kheradmand, P. P. Trivedi, N. A. Wolf, P. C. Roberts, and R. H. Swanborg
Characterization of a subset of bone marrow-derived natural killer cells that regulates T cell activation in rats
J. Leukoc. Biol., May 1, 2008; 83(5): 1128 - 1135.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
L. L. Veinotte, T. Y. F. Halim, and F. Takei
Unique subset of natural killer cells develops from progenitors in lymph node
Blood, April 15, 2008; 111(8): 4201 - 4208.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Silva, D. M. Andrews, A. G. Brooks, M. J. Smyth, and Y. Hayakawa
Application of CD27 as a marker for distinguishing human NK cell subsets
Int. Immunol., April 1, 2008; 20(4): 625 - 630.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. T. M. Vossen, M. Matmati, K. M. L. Hertoghs, P. A. Baars, M.-R. Gent, G. Leclercq, J. Hamann, T. W. Kuijpers, and R. A. W. van Lier
CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets
J. Immunol., March 15, 2008; 180(6): 3739 - 3745.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
E. Alici, T. Sutlu, B. Bjorkstrand, M. Gilljam, B. Stellan, H. Nahi, H. C. Quezada, G. Gahrton, H.-G. Ljunggren, and M. S. Dilber
Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components
Blood, March 15, 2008; 111(6): 3155 - 3162.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Pilbeam, P. Basse, L. Brossay, N. Vujanovic, R. Gerstein, A. N. Vallejo, and L. Borghesi
The Ontogeny and Fate of NK Cells Marked by Permanent DNA Rearrangements
J. Immunol., February 1, 2008; 180(3): 1432 - 1441.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
Y. Hayakawa, S. V. Watt, K. Takeda, and M. J. Smyth
Distinct receptor repertoire formation in mouse NK cell subsets regulated by MHC class I expression
J. Leukoc. Biol., January 1, 2008; 83(1): 106 - 111.
[Abstract] [Full Text] [PDF]

Home page
 JEMHome page
A. L. Blasius, W. Barchet, M. Cella, and M. Colonna
Development and function of murine B220+CD11c+NK1.1+ cells identify them as a subset of NK cells
J. Exp. Med., October 29, 2007; 204(11): 2561 - 2568.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. D. Huntington, H. Tabarias, K. Fairfax, J. Brady, Y. Hayakawa, M. A. Degli-Esposti, M. J. Smyth, D. M. Tarlinton, and S. L. Nutt
NK Cell Maturation and Peripheral Homeostasis Is Associated with KLRG1 Up-Regulation
J. Immunol., April 15, 2007; 178(8): 4764 - 4770.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
C. Coban, K. J. Ishii, S. Uematsu, N. Arisue, S. Sato, M. Yamamoto, T. Kawai, O. Takeuchi, H. Hisaeda, T. Horii, et al.
Pathological role of Toll-like receptor signaling in cerebral malaria
Int. Immunol., January 1, 2007; 19(1): 67 - 79.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
T. C. Walser, S. Rifat, X. Ma, N. Kundu, C. Ward, O. Goloubeva, M. G. Johnson, J. C. Medina, T. L. Collins, and A. M. Fulton
Antagonism of CXCR3 Inhibits Lung Metastasis in a Murine Model of Metastatic Breast Cancer.
Cancer Res., August 1, 2006; 66(15): 7701 - 7707.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.