The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Mizoguchi, A.
Right arrow Articles by Bhan, A. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Mizoguchi, A.
Right arrow Articles by Bhan, A. K.
The Journal of Immunology, 2006, 176: 705-710.
Copyright © 2006 by The American Association of Immunologists

BRIEF REVIEWS

A Case for Regulatory B Cells1

Atsushi Mizoguchi and Atul K. Bhan2

Immunopathology Unit, Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114

B cells are typically characterized by their ability to produce Abs, including autoantibodies. However, B cells possess additional immune functions, including the production of cytokines and the ability to function as a secondary APC. As with T cells, the B cell population contains functionally distinct subsets capable of performing both pathogenic and regulatory functions. Recent studies indicate that regulatory B cells develop in several murine models of chronic inflammation, including inflammatory bowel disease, rheumatoid arthritis, and experimental autoimmune encephalomyelitis. The regulatory function may be directly accomplished by the production of regulatory cytokines IL-10 and TGF-{beta} and/or by the ability of B cells to interact with pathogenic T cells to dampen harmful immune responses. In this review, we make a case for the existence of regulatory B cells and discuss the possible developmental pathways and functional mechanisms of these B cells.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
K. Yanaba, J.-D. Bouaziz, T. Matsushita, T. Tsubata, and T. F. Tedder
The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals
J. Immunol., June 15, 2009; 182(12): 7459 - 7472.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
K. A. Markey, T. Banovic, R. D. Kuns, S. D. Olver, A. L. J. Don, N. C. Raffelt, Y. A. Wilson, L. J. Raggatt, A. R. Pettit, J. S. Bromberg, et al.
Conventional dendritic cells are the critical donor APC presenting alloantigen after experimental bone marrow transplantation
Blood, May 28, 2009; 113(22): 5644 - 5649.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J.-B. Sun, C.-F. Flach, C. Czerkinsky, and J. Holmgren
B Lymphocytes Promote Expansion of Regulatory T Cells in Oral Tolerance: Powerful Induction by Antigen Coupled to Cholera Toxin B Subunit
J. Immunol., December 15, 2008; 181(12): 8278 - 8287.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
D Albert, J Dunham, S Khan, J Stansberry, S Kolasinski, D Tsai, S Pullman-Mooar, F Barnack, C Striebich, R J Looney, et al.
Variability in the biological response to anti-CD20 B cell depletion in systemic lupus erythaematosus
Ann Rheum Dis, December 1, 2008; 67(12): 1724 - 1731.
[Abstract] [Full Text] [PDF]

Home page
 Ann Rheum DisHome page
C B Driver, M Ishimori, and M H Weisman
The B cell in systemic lupus erythaematosus: a rational target for more effective therapy
Ann Rheum Dis, October 1, 2008; 67(10): 1374 - 1381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
M. McPherson, B. Wei, O. Turovskaya, D. Fujiwara, S. Brewer, and J. Braun
Colitis immunoregulation by CD8+ T cell requires T cell cytotoxicity and B cell peptide antigen presentation
Am J Physiol Gastrointest Liver Physiol, September 1, 2008; 295(3): G485 - G492.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
T. W. LeBien and T. F. Tedder
B lymphocytes: how they develop and function
Blood, September 1, 2008; 112(5): 1570 - 1580.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
T. Fehr, F. Haspot, J. Mollov, M. Chittenden, T. Hogan, and M. Sykes
Alloreactive CD8 T Cell Tolerance Requires Recipient B Cells, Dendritic Cells, and MHC Class II
J. Immunol., July 1, 2008; 181(1): 165 - 173.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
Y. Shimomura, E. Mizoguchi, K. Sugimoto, R. Kibe, Y. Benno, A. Mizoguchi, and A. K. Bhan
Regulatory role of B-1 B cells in chronic colitis
Int. Immunol., June 1, 2008; 20(6): 729 - 737.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. Singh, W. F. Carson IV, E. R. Secor Jr, L. A. Guernsey, R. A. Flavell, R. B. Clark, R. S. Thrall, and C. M. Schramm
Regulatory Role of B Cells in a Murine Model of Allergic Airway Disease
J. Immunol., June 1, 2008; 180(11): 7318 - 7326.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Yu, R. Dunn, M. R. Kehry, and H. Braley-Mullen
B Cell Depletion Inhibits Spontaneous Autoimmune Thyroiditis in NOD.H-2h4 Mice
J. Immunol., June 1, 2008; 180(11): 7706 - 7713.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
K. Kalies, P. Konig, Y.-M. Zhang, M. Deierling, J. Barthelmann, C. Stamm, and J. Westermann
Nonoverlapping Expression of IL10, IL12p40, and IFN{gamma} mRNA in the Marginal Zone and T Cell Zone of the Spleen after Antigenic Stimulation
J. Immunol., April 15, 2008; 180(8): 5457 - 5465.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
P. Velazquez, B. Wei, M. McPherson, L. M. A. Mendoza, S. L. Nguyen, O. Turovskaya, M. Kronenberg, T. T. Huang, M. Schrage, L. N. Lobato, et al.
Villous B Cells of the Small Intestine Are Specialized for Invariant NK T Cell Dependence
J. Immunol., April 1, 2008; 180(7): 4629 - 4638.
[Abstract] [Full Text] [PDF]

Home page
 Int ImmunolHome page
A. Pellegrini, N. Guinazu, M. P. Aoki, I. C. Calero, E. A. Carrera-Silva, N. Girones, M. Fresno, and S. Gea
Spleen B cells from BALB/c are more prone to activation than spleen B cells from C57BL/6 mice during a secondary immune response to cruzipain
Int. Immunol., December 1, 2007; 19(12): 1395 - 1402.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
M. Ostrowski, M. Vermeulen, O. Zabal, P. I. Zamorano, A. M. Sadir, J. R. Geffner, and O. J. Lopez
The Early Protective Thymus-Independent Antibody Response to Foot-and-Mouth Disease Virus Is Mediated by Splenic CD9+ B Lymphocytes
J. Virol., September 1, 2007; 81(17): 9357 - 9367.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
P. Reichardt, B. Dornbach, S. Rong, S. Beissert, F. Gueler, K. Loser, and M. Gunzer
Naive B cells generate regulatory T cells in the presence of a mature immunologic synapse
Blood, September 1, 2007; 110(5): 1519 - 1529.
[Abstract] [Full Text] [PDF]

Home page
 J Am Coll CardiolHome page
C. J. Binder, K. Hartvigsen, and J. L. Witztum
Promise of Immune Modulation to Inhibit Atherogenesis
J. Am. Coll. Cardiol., August 7, 2007; 50(6): 547 - 550.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
W. E. Walker and D. R. Goldstein
Neonatal B Cells Suppress Innate Toll-Like Receptor Immune Responses and Modulate Alloimmunity
J. Immunol., August 1, 2007; 179(3): 1700 - 1710.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
R. Watanabe, M. Fujimoto, N. Ishiura, Y. Kuwano, H. Nakashima, N. Yazawa, H. Okochi, S. Sato, T. F. Tedder, and K. Tamaki
CD19 Expression in B Cells Is Important for Suppression of Contact Hypersensitivity
Am. J. Pathol., August 1, 2007; 171(2): 560 - 570.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
K. Odunsi, F. Qian, J. Matsuzaki, P. Mhawech-Fauceglia, C. Andrews, E. W. Hoffman, L. Pan, G. Ritter, J. Villella, B. Thomas, et al.
Vaccination with an NY-ESO-1 peptide of HLA class I/II specificities induces integrated humoral and T cell responses in ovarian cancer
PNAS, July 31, 2007; 104(31): 12837 - 12842.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
J. Rosenblatt, Y. D. Zhang, and T. Tadmor
Inhibition of Antitumor Immunity by B Cells
Cancer Res., May 15, 2007; 67(10): 5058 - 5058.
[Full Text] [PDF]

Home page
 Cancer Res.Home page
S. Inoue, D. Scott, B. Golding, and W. W. Leitner
Regulatory B Cells Inhibit Antitumor Immunity
Cancer Res., May 15, 2007; 67(10): 5059 - 5059.
[Full Text] [PDF]

Home page
 J. Immunol.Home page
M. Duddy, M. Niino, F. Adatia, S. Hebert, M. Freedman, H. Atkins, H. J. Kim, and A. Bar-Or
Distinct Effector Cytokine Profiles of Memory and Naive Human B Cell Subsets and Implication in Multiple Sclerosis
J. Immunol., May 15, 2007; 178(10): 6092 - 6099.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. K. Mann, K. Maresz, L. P. Shriver, Y. Tan, and B. N. Dittel
B Cell Regulation of CD4+CD25+ T Regulatory Cells and IL-10 Via B7 is Essential for Recovery From Experimental Autoimmune Encephalomyelitis
J. Immunol., March 15, 2007; 178(6): 3447 - 3456.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
C. J. Callaghan, F. J. Rouhani, M. C. Negus, A. J. Curry, E. M. Bolton, J. A. Bradley, and G. J. Pettigrew
Abrogation of Antibody-Mediated Allograft Rejection by Regulatory CD4 T Cells with Indirect Allospecificity
J. Immunol., February 15, 2007; 178(4): 2221 - 2228.
[Abstract] [Full Text] [PDF]

Home page
 NEJMHome page
A. R. Ahmed, Z. Spigelman, L. A. Cavacini, and M. R. Posner
Treatment of Pemphigus Vulgaris with Rituximab and Intravenous Immune Globulin
N. Engl. J. Med., October 26, 2006; 355(17): 1772 - 1779.
[Abstract] [Full Text] [PDF]

Home page
 BloodHome page
V. Rowe, T. Banovic, K. P. MacDonald, R. Kuns, A. L. Don, E. S. Morris, A. C. Burman, H. M. Bofinger, A. D. Clouston, and G. R. Hill
Host B cells produce IL-10 following TBI and attenuate acute GVHD after allogeneic bone marrow transplantation
Blood, October 1, 2006; 108(7): 2485 - 2492.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.