The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow Request Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Papathanassoglou, E.
Right arrow Articles by Mantzoros, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Papathanassoglou, E.
Right arrow Articles by Mantzoros, C.
The Journal of Immunology, 2006, 176: 7745-7752.
Copyright © 2006 by The American Association of Immunologists

Leptin Receptor Expression and Signaling in Lymphocytes: Kinetics During Lymphocyte Activation, Role in Lymphocyte Survival, and Response to High Fat Diet in Mice1

Elizabeth Papathanassoglou*, Karim El-Haschimi*, Xian Chang Li{dagger}, Giuseppe Matarese{ddagger}, Terry Strom{dagger} and Christos Mantzoros2,*

* Division of Endocrinology, Diabetes, and Metabolism, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; {dagger} Division of Immunology, Transplant Research Center, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215; and {ddagger} Gruppo di ImmunoEndocrinologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Napoli, Italy

Leptin has direct effects not only on neuroendocrine function and metabolism, but also on T cell-mediated immunity. We report in this study that leptin receptor (ObR) is expressed on resting normal mouse CD4+, CD8+, B cells, and monocyte/macrophages. ObR expression is up-regulated following cell activation, but with different kinetics, in different lymphocyte subsets. Leptin binding to ObR results in increased STAT-3 activation in T cells, with a different activation pattern in resting vs anti-CD3 Ab stimulated T cells. Leptin also promotes lymphocyte survival in vitro by suppressing Fas-mediated apoptosis. B lymphocytes appear to be more susceptible to the antiapoptotic effects of leptin, and they show higher surface expression of ObR, compared with T cells. Moreover, CD4+ T cells isolated from ObR-deficient mice displayed a reduced proliferative response, compared with normal controls. Furthermore, ObR/STAT-3-mediated signaling in T lymphocytes is decreased in the diet-induced obese mouse model of obesity and leptin resistance. In summary, our findings show that the ObR is expressed on normal mouse lymphocyte subsets, that leptin plays a role in lymphocyte survival, and that leptin alters the ObR/STAT-3-mediated signaling in T cells. Taken together, our data further support the notion that nutritional status acting via leptin-dependent mechanisms may alter the nature and vigor of the immune response.




This article has been cited by other articles:


Home page
 Am. J. Physiol. Gastrointest. Liver Physiol.Home page
N. P. Hyland, A. P. Chambers, C. M. Keenan, Q. J. Pittman, and K. A. Sharkey
Differential adipokine response in genetically predisposed lean and obese rats during inflammation: a role in modulating experimental colitis?
Am J Physiol Gastrointest Liver Physiol, November 1, 2009; 297(5): G869 - G877.
[Abstract] [Full Text] [PDF]

Home page
 J EndocrinolHome page
A. L Gruver, M. S Ventevogel, and G. D Sempowski
Leptin receptor is expressed in thymus medulla and leptin protects against thymic remodeling during endotoxemia-induced thymus involution
J. Endocrinol., October 1, 2009; 203(1): 75 - 85.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Clin. Nutr.Home page
S. Bluher and C. S Mantzoros
Leptin in humans: lessons from translational research
Am. J. Clinical Nutrition, March 1, 2009; 89(3): 991S - 997S.
[Abstract] [Full Text] [PDF]

Home page
 The Journal of RheumatologyHome page
E. A. AGUILAR-CHAVEZ, J. I. GAMEZ-NAVA, M. A. LOPEZ-OLIVO, S. GALVAN-MELENDRES, E. G. CORONA-SANCHEZ, C. A. LOAIZA-CARDENAS, A. CELIS, E. G. CARDONA-MUNOZ, and L. GONZALEZ-LOPEZ
Circulating Leptin and Bone Mineral Density in Rheumatoid Arthritis
J Rheumatol, March 1, 2009; 36(3): 512 - 516.
[Abstract] [Full Text] [PDF]

Home page
 J. Leukoc. Biol.Home page
N. J. MacIver, S. R. Jacobs, H. L. Wieman, J. A. Wofford, J. L. Coloff, and J. C. Rathmell
Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival
J. Leukoc. Biol., October 1, 2008; 84(4): 949 - 957.
[Abstract] [Full Text] [PDF]

Home page
 Epidemiol RevHome page
S. Musaad and E. N. Haynes
Biomarkers of Obesity and Subsequent Cardiovascular Events
Epidemiol. Rev., May 10, 2007; (2007) mxm005v1.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
A. G. Smith, P. A. Sheridan, J. B. Harp, and M. A. Beck
Diet-Induced Obese Mice Have Increased Mortality and Altered Immune Responses When Infected with Influenza Virus
J. Nutr., May 1, 2007; 137(5): 1236 - 1243.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
L. Macia, M. Delacre, G. Abboud, T.-S. Ouk, A. Delanoye, C. Verwaerde, P. Saule, and I. Wolowczuk
Impairment of Dendritic Cell Functionality and Steady-State Number in Obese Mice
J. Immunol., November 1, 2006; 177(9): 5997 - 6006.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.