| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
* Medical Research Council (MRC) Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom;
MRC Laboratories Fajara, Banjul, The Gambia, West Africa; and
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892
Unlike HIV-1-infected people, most HIV-2-infected subjects maintain a healthy CD4+ T cell count and a strong HIV-specific CD4+ T cell response. To define the cellular immunological correlates of good prognosis in HIV-2 infection, we conducted a cross-sectional study of HIV Gag-specific T cell function in HIV-1- and HIV-2-infected Gambians. Using cytokine flow cytometry and lymphoproliferation assays, we show that HIV-specific CD4+ T cells from HIV-2-infected individuals maintained proliferative capacity, were not terminally differentiated (CD57–), and more frequently produced IFN-
or IL-2 than CD4+ T cells from HIV-1-infected donors. Polyfunctional (IFN-+/IL-2+) HIV-specific CD4+ T cells were found exclusively in HIV-2+ donors. The disparity in CD4+ T cell responses between asymptomatic HIV-1- and HIV-2-infected subjects was not associated with differences in the proliferative capacity of HIV-specific CD8+ T cells. This study demonstrates that HIV-2-infected donors have a well-preserved and functionally heterogeneous HIV-specific memory CD4+ T cell response that is associated with delayed disease progression in the majority of infected people.
This article has been cited by other articles:
|
|
 |
|
  M. G. Duvall, K. Lore, H. Blaak, D. A. Ambrozak, W. C. Adams, K. Santos, C. Geldmacher, J. R. Mascola, A. J. McMichael, A. Jaye, et al. Dendritic Cells Are Less Susceptible to Human Immunodeficiency Virus Type 2 (HIV-2) Infection than to HIV-1 Infection J. Virol., December 15, 2007; 81(24): 13486 - 13498. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. N. Zheng, M. J. McElrath, P.-S. Sow, S. E. Hawes, H. Diallo-Agne, J. E. Stern, F. Li, A. L. Mesher, A. D. Robinson, G. S. Gottlieb, et al. Role of Human Immunodeficiency Virus (HIV)-Specific T-Cell Immunity in Control of Dual HIV-1 and HIV-2 Infection J. Virol., September 1, 2007; 81(17): 9061 - 9071. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Kannanganat, C. Ibegbu, L. Chennareddi, H. L. Robinson, and R. R. Amara Multiple-Cytokine-Producing Antiviral CD4 T Cells Are Functionally Superior to Single-Cytokine-Producing Cells J. Virol., August 15, 2007; 81(16): 8468 - 8476. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, S. R. Permar, A. P. Buzby, and N. L. Letvin Memory CD4+ T-Lymphocyte Loss and Dysfunction during Primary Simian Immunodeficiency Virus Infection J. Virol., August 1, 2007; 81(15): 8009 - 8015. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. A. Millington, J. A. Innes, S. Hackforth, T. S. C. Hinks, J. J. Deeks, D. P. S. Dosanjh, V. Guyot-Revol, R. Gunatheesan, P. Klenerman, and A. Lalvani Dynamic Relationship between IFN-{gamma} and IL-2 Profile of Mycobacterium tuberculosis-Specific T Cells and Antigen Load J. Immunol., April 15, 2007; 178(8): 5217 - 5226. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
