HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Related articles in The JI Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Dooley, J. Articles by Farr, A. G. Search for Related Content PubMed PubMed Citation Articles by Dooley, J. Articles by Farr, A. G.

Cervical Thymus in the Mouse¹

James Dooley^*, Matthew Erickson^*, Geoffrey O. Gillard and Andrew G. Farr^2,*,

^* Department of Biological Structure and Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195

Although thymic ectopy has long been recognized in humans, the functional activity or potential immunological significance of this thymic tissue is unknown. In this study, we describe murine thymic ectopy, cervical thymic tissue that possesses the same general organization as the thoracic thymus, that is able to support T cell differentiation, and that can export T cells to the periphery. Unexpectedly, the pattern of autoantigen expression by ectopic thymic tissue differs from that of the thoracic thymus, raising the possibility that these two thymic environments may project different versions of self.

Related articles in The JI:

IN THIS ISSUE

The JI 2006 176: 6365-6366. [Full Text]  

This article has been cited by other articles:

				G. O. Gillard, J. Dooley, M. Erickson, L. Peltonen, and A. G. Farr Aire-Dependent Alterations in Medullary Thymic Epithelium Indicate a Role for Aire in Thymic Epithelial Differentiation J. Immunol., March 1, 2007; 178(5): 3007 - 3015. [Abstract] [Full Text] [PDF]