| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
BRIEF REVIEWS |
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104
The BLyS family of ligands and receptors governs B cell homeostasis by controlling survival, differentiation, and lifespan. This family consists of multiple receptors and ligands, allowing independent regulation of different B cell subsets by varying the combination and levels of receptors expressed. Multiple downstream signaling pathways are implicated in these activities, reflecting this receptor complexity as well as cross-talk with other B cell signaling systems. BLyS levels are associated with multiple forms of humoral autoimmunity and can modulate tolerogenic elimination at the transitional checkpoint. BLyS responsiveness thus balances peripheral selection against cell numbers, providing an elastic system that varies selective stringency based on homeostatic demands.
This article has been cited by other articles:
|
|
 |
|
  S. Sarantopoulos, K. E. Stevenson, H. T. Kim, C. S. Cutler, N. S. Bhuiya, M. Schowalter, V. T. Ho, E. P. Alyea, J. Koreth, B. R. Blazar, et al. Altered B-cell homeostasis and excess BAFF in human chronic graft-versus-host disease Blood, April 16, 2009; 113(16): 3865 - 3874. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Zekavat, S. Y. Rostami, A. Badkerhanian, R. F. Parsons, B. Koeberlein, M. Yu, C. D. Ward, T.-S. Migone, L. Yu, G. S. Eisenbarth, et al. In Vivo BLyS/BAFF Neutralization Ameliorates Islet-Directed Autoimmunity in Nonobese Diabetic Mice J. Immunol., December 1, 2008; 181(11): 8133 - 8144. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. M. Guerrettaz, S. A. Johnson, and J. C. Cambier Acquired hematopoietic stem cell defects determine B-cell repertoire changes associated with aging PNAS, August 19, 2008; 105(33): 11898 - 11902. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. Harigai, M. Kawamoto, M. Hara, T. Kubota, N. Kamatani, and N. Miyasaka Excessive Production of IFN-{gamma} in Patients with Systemic Lupus Erythematosus and Its Contribution to Induction of B Lymphocyte Stimulator/B Cell-Activating Factor/TNF Ligand Superfamily-13B J. Immunol., August 1, 2008; 181(3): 2211 - 2219. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X. Li, K. Su, C. Ji, A. J. Szalai, J. Wu, Y. Zhang, T. Zhou, R. P. Kimberly, and J. C. Edberg Immune Opsonins Modulate BLyS/BAFF Release in a Receptor-Specific Fashion J. Immunol., July 15, 2008; 181(2): 1012 - 1018. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Xu, P. A. Santini, A. J. Matthews, A. Chiu, A. Plebani, B. He, K. Chen, and A. Cerutti Viral Double-Stranded RNA Triggers Ig Class Switching by Activating Upper Respiratory Mucosa B Cells through an Innate TLR3 Pathway Involving BAFF J. Immunol., July 1, 2008; 181(1): 276 - 287. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G Cambridge, D A Isenberg, J C W Edwards, M J Leandro, T-S Migone, M Teodorescu, and W Stohl B cell depletion therapy in systemic lupus erythaematosus: relationships among serum B lymphocyte stimulator levels, autoantibody profile and clinical response Ann Rheum Dis, July 1, 2008; 67(7): 1011 - 1016. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. L. Langat, D. A. Wheaton, J. S. Platt, T. Sifers, and J. S. Hunt Signaling Pathways for B Cell-Activating Factor (BAFF) and a Proliferation-Inducing Ligand (APRIL) in Human Placenta Am. J. Pathol., May 1, 2008; 172(5): 1303 - 1311. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
F. Lavie, C. Miceli-Richard, M. Ittah, J. Sellam, J.-E. Gottenberg, and X. Mariette Increase of B cell-activating factor of the TNF family (BAFF) after rituximab treatment: insights into a new regulating system of BAFF production Ann Rheum Dis, May 1, 2007; 66(5): 700 - 702. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M P Cancro The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity Ann Rheum Dis, November 1, 2006; 65(suppl_3): iii34 - iii36. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
