| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
under Arthritic Conditions1
* Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, the Netherlands;
Children’s Hospital of Pittsburgh, Department of Pediatric and Pulmonology, Pittsburgh, PA 15213;
Novartis Institutes for Biomedical Research, Basel, Switzerland
The proinflammatory T cell cytokine IL-17 is a potent inducer of other cytokines such as IL-1 and TNF-
. The contribution of TNF in IL-17-induced joint inflammation is unclear. In this work we demonstrate using TNF--deficient mice that TNF- is required in IL-17-induced joint pathology under naive conditions in vivo. However, overexpression of IL-17 aggravated K/BxN serum transfer arthritis to a similar degree in TNF--deficient mice and their wild-type counterparts, indicating that the TNF dependency of IL-17-induced pathology is lost under arthritic conditions. Also, during the course of the streptococcal cell wall-induced arthritis model, IL-17 was able to enhance inflammation and cartilage damage in the absence of TNF. Additional blocking of IL-1 during IL-17-enhanced streptococcal cell wall-induced arthritis did not reduce joint pathology in TNF-deficient mice, indicating that IL-1 is not responsible for this loss of TNF dependency. These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions.
This article has been cited by other articles:
|
|
 |
|
  C. R. Crowe, K. Chen, D. A. Pociask, J. F. Alcorn, C. Krivich, R. I. Enelow, T. M. Ross, J. L. Witztum, and J. K. Kolls Critical Role of IL-17RA in Immunopathology of Influenza Infection J. Immunol., October 15, 2009; 183(8): 5301 - 5310. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Nistala and L. R. Wedderburn Th17 and regulatory T cells: rebalancing pro- and anti-inflammatory forces in autoimmune arthritis Rheumatology, June 1, 2009; 48(6): 602 - 606. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C Plater-Zyberk, L A B Joosten, M M A Helsen, M I Koenders, P A Baeuerle, and W B van den Berg Combined blockade of granulocyte-macrophage colony stimulating factor and interleukin 17 pathways potently suppresses chronic destructive arthritis in a tumour necrosis factor {alpha}-independent mouse model Ann Rheum Dis, May 1, 2009; 68(5): 721 - 728. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Jang, S.-H. Cho, H. Park, D.-J. Paik, J. M. Kim, and J. Youn A Positive Feedback Loop of IL-21 Signaling Provoked by Homeostatic CD4+CD25- T Cell Expansion Is Essential for the Development of Arthritis in Autoimmune K/BxN Mice J. Immunol., April 15, 2009; 182(8): 4649 - 4656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. G. Evans, N. J. Gullick, S. Kelly, C. Pitzalis, G. M. Lord, B. W. Kirkham, and L. S. Taams In vivo activated monocytes from the site of inflammation in humans specifically promote Th17 responses PNAS, April 14, 2009; 106(15): 6232 - 6237. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. Chizzolini, R. Chicheportiche, M. Alvarez, C. de Rham, P. Roux-Lombard, S. Ferrari-Lacraz, and J.-M. Dayer Prostaglandin E2 synergistically with interleukin-23 favors human Th17 expansion Blood, November 1, 2008; 112(9): 3696 - 3703. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Cihakova, J. G. Barin, M. Afanasyeva, M. Kimura, D. Fairweather, M. Berg, M. V. Talor, G. C. Baldeviano, S. Frisancho, K. Gabrielson, et al. Interleukin-13 Protects Against Experimental Autoimmune Myocarditis by Regulating Macrophage Differentiation Am. J. Pathol., May 1, 2008; 172(5): 1195 - 1208. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Yamaguchi, K. Fujio, H. Shoda, A. Okamoto, N. H. Tsuno, K. Takahashi, and K. Yamamoto IL-17B and IL-17C Are Associated with TNF-{alpha} Production and Contribute to the Exacerbation of Inflammatory Arthritis J. Immunol., November 15, 2007; 179(10): 7128 - 7136. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. B van den Berg, P. L van Lent, L. A B Joosten, S. Abdollahi-Roodsaz, and M. I Koenders Amplifying elements of arthritis and joint destruction Ann Rheum Dis, November 1, 2007; 66(suppl_3): iii45 - iii48. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. N. Patel, C. A. King, S. R. Bailey, J. W. Holt, K. Venkatachalam, A. Agrawal, A. J. Valente, and B. Chandrasekar Interleukin-17 Stimulates C-reactive Protein Expression in Hepatocytes and Smooth Muscle Cells via p38 MAPK and ERK1/2-dependent NF-{kappa}B and C/EBPbeta Activation J. Biol. Chem., September 14, 2007; 282(37): 27229 - 27238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M I Koenders, L A B Joosten, and W B van den Berg Potential new targets in arthritis therapy: interleukin (IL)-17 and its relation to tumour necrosis factor and IL-1 in experimental arthritis Ann Rheum Dis, November 1, 2006; 65(suppl_3): iii29 - iii33. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
