The JI
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     
 

This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Veldhoen, M.
Right arrow Articles by Stockinger, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Veldhoen, M.
Right arrow Articles by Stockinger, B.
The Journal of Immunology, 2006, 176: 6202-6210.
Copyright © 2006 by The American Association of Immunologists

Modulation of Dendritic Cell Function by Naive and Regulatory CD4+ T Cells1

Marc Veldhoen, Halima Moncrieffe, Richard J. Hocking, Christopher J. Atkins and Brigitta Stockinger2

Division of Molecular Immunology, the Medical Research Council, National Institute for Medical Research, London, United Kingdom

The consequences of interactions between dendric cells (DCs) and either naive CD4+ T cells or regulatory CD4+CD25+ T cells on the expression of proinflammatory IL-6 and anti-inflammatory IL-10 in DC were examined over a period of 12 h, spanning the time frame during which stable T cell–DC interactions shape the development of tolerance and immunity in vivo. We demonstrate that the basal production of IL-6 and IL-10, which is initiated following DC stimulation with LPS, is modified in distinctly different ways by interaction with the two T cell populations. Naive CD4 T cells skew DC cytokine production toward IL-6 and suppress IL-10, whereas CD4+CD25+ T cells have the opposite effect. CD8 T cells or memory CD4 T cells do not influence basal cytokine production by stimulated DC. The effect of CD4+CD25+ T cells is dominant in coculture with naive CD4 T cells as long as inflammatory LPS is absent; the addition of LPS abrogates the suppression of IL-6. However, the modulating influence of CD4+CD25+ T cells remains evident in the enhancement of IL-10 production. Thus, mutual interactions between DC and CD4+ T cell subpopulations following contact with pathogens are likely to influence the strength and quality of incipient immune responses in the local microenvironment.




This article has been cited by other articles:


Home page
 J. Immunol.Home page
G. H. Stummvoll, R. J. DiPaolo, E. N. Huter, T. S. Davidson, D. Glass, J. M. Ward, and E. M. Shevach
Th1, Th2, and Th17 Effector T Cell-Induced Autoimmune Gastritis Differs in Pathological Pattern and in Susceptibility to Suppression by Regulatory T Cells
J. Immunol., August 1, 2008; 181(3): 1908 - 1916.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
Y. Onishi, Z. Fehervari, T. Yamaguchi, and S. Sakaguchi
Foxp3+ natural regulatory T cells preferentially form aggregates on dendritic cells in vitro and actively inhibit their maturation
PNAS, July 22, 2008; 105(29): 10113 - 10118.
[Abstract] [Full Text] [PDF]

Home page
 Infect. Immun.Home page
C. V. Poncini, C. D. A. Soto, E. Batalla, M. E. Solana, and S. M. Gonzalez Cappa
Trypanosoma cruzi Induces Regulatory Dendritic Cells In Vitro
Infect. Immun., June 1, 2008; 76(6): 2633 - 2641.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
S. Piconese, B. Valzasina, and M. P. Colombo
OX40 triggering blocks suppression by regulatory T cells and facilitates tumor rejection
J. Exp. Med., April 14, 2008; 205(4): 825 - 839.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
A. W. T. Lau, S. Biester, R. J. Cornall, and J. V. Forrester
Lipopolysaccharide-Activated IL-10-Secreting Dendritic Cells Suppress Experimental Autoimmune Uveoretinitis by MHCII-Dependent Activation of CD62L-Expressing Regulatory T Cells
J. Immunol., March 15, 2008; 180(6): 3889 - 3899.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
N. Asano, T. Watanabe, A. Kitani, I. J. Fuss, and W. Strober
Notch1 Signaling and Regulatory T Cell Function
J. Immunol., March 1, 2008; 180(5): 2796 - 2804.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
J. Hanig and M. B. Lutz
Suppression of Mature Dendritic Cell Function by Regulatory T Cells In Vivo Is Abrogated by CD40 Licensing
J. Immunol., February 1, 2008; 180(3): 1405 - 1413.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
R. J. DiPaolo, C. Brinster, T. S. Davidson, J. Andersson, D. Glass, and E. M. Shevach
Autoantigen-Specific TGFbeta-Induced Foxp3+ Regulatory T Cells Prevent Autoimmunity by Inhibiting Dendritic Cells from Activating Autoreactive T Cells
J. Immunol., October 1, 2007; 179(7): 4685 - 4693.
[Abstract] [Full Text] [PDF]

Home page
 J. Nutr.Home page
B. Corthesy, H. R. Gaskins, and A. Mercenier
Cross-Talk between Probiotic Bacteria and the Host Immune System
J. Nutr., March 1, 2007; 137(3): 781S - 790S.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
M. J. Anderson, K. Shafer-Weaver, N. M. Greenberg, and A. A. Hurwitz
Tolerization of Tumor-Specific T Cells Despite Efficient Initial Priming in a Primary Murine Model of Prostate Cancer
J. Immunol., February 1, 2007; 178(3): 1268 - 1276.
[Abstract] [Full Text] [PDF]

Home page
 J. Immunol.Home page
S. Wan, C. Xia, and L. Morel
IL-6 Produced by Dendritic Cells from Lupus-Prone Mice Inhibits CD4+CD25+ T Cell Regulatory Functions
J. Immunol., January 1, 2007; 178(1): 271 - 279.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Website Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.
All Contents Copyright © 2006 by The American Association of Immunologists, Inc. All rights reserved.